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Implication
of Interleukin-4 in Wound Healing
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Véronique
Salmon-Ehr, Laurent Ramont, Gaston Godeau, Philippe Birembaut, Moncef Guenounou,
Philippe Bernard, and François-Xavier Maquart
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Laboratoire
de Biochimie et Biologie Moléculaire et Laboratoire de Recherche
Biomédicale en Dermatologie-UPRESA CNRS 6021 (VS-E, LR, PBe, F-XM),
and Laboratoire d'Histologie INSERM U314(PBi), and Laboratoire des Cytokines
(UPRES-EA 2070) (MG), IFR-53 Biomolécules, Faculté de Médecine,
Reims Cedex; and Laboratoire de Biochimie et Analise d'Images (GG), Faculté
d'Odontologie, Montrouge, France
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SUMMARY: Interleukin-4 (IL-4) is a pleiotropic cytokine that is able
to activate connective tissue cells and stimulate the accumulation of
extracellular matrix macromolecules. In this report, the expression of
IL-4 in normal wound healing was studied by immunohistochemistry. The
effects of exogenous IL-4 or IL-4 antisense oligonucleotides administration
were also studied in mouse experimental wounds. IL-4 expression was detected
in the lower dermis below the wound as early as Day 1 after wounding.
IL-4 expression was maximal by Day 4, then decreased progressively, and
completely disappeared by Day 21 after wounding. Topical administration
of IL-4 on experimental wounds in mice significantly accelerated the rate
of healing, whereas IL-4 antisense oligonucleotides significantly inhibited
healing. These results demonstrate that IL-4 may be implicated in normal
wound healing.
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