Adminstrative Core
Molecular Core
Physiology Core
Cell Core
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Pilot & Feasibility Program
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DIRECTOR
Thomas O.Carpenter, M.D
Tom is a pediatric endocrinologist with a long-standing interest in vitamin and mineral metabolism.
He has investigated the regulation of phosphate homeostasis in humans and other mammalian systems throughout his career, with particular attention to the study of clinical disorders of calcium and phosphate metabolism.He has extensive experience in cell culture studies, as well as both animal and human investigation. He has recently focused attention on magnesium's role in the acquisition of skeletal mass. He has published several important papers on the effects of magnesium depletion on bone mass in experimental animals.

General Overview
The primary aim of the Physiology Core is to offer core members comprehensive, state-of-the-art, physiologic assessment of bone metabolism in animal models of musculoskeletal disease. A secondary aim of the Core is to offer specific training in these procedures to the technical staff, fellows, and junior faculty in laboratories of Core investigators.

Last Edited
July 12,2001 TD

Core Services

    1. Preparation of undecalcified tissue sections and specialized staining of bone from animal models of disease, such as in genetically engineered mice (eg, PTHrP knockout mice).

2. Interpretation of static and dynamic parameters of bone histomorphometric analysis.

3. Measurement of biochemical markers of bone turnover in serum and urine collected in animal studies, and measurement of bone cell markers from cell and organ culture experiments.

4. Assessment of bone mineral density ex vivo using peripheral quantitative computed tomography.

5. Provide instruction to technical staff, fellows, and junior faculty with research interests coincident with the mission of the Core.