Fred Wright, M.D.

Professor of Medicine, and Cellular and Molecular Physiology
Associate Chief of Staff for Research, VA Connecticut Health Care Systems

B.A., 1959: University of Michigan
M.D., 1963: University of Michigan
Residency: Johns Hopkins Hospital
Fellowships: LKEM, NIH

E-mail: fred.wright@yale.edu

Our laboratory is focused on cellular mechanisms involved in electrolyte transport by proximal and distal renal tubules, and on components of the intrarenal mechanism responsible for feedback control of glomerular filtration rate. Experimental approaches include both in vivo microperfusion of surface segments, and in vitro perfusion of isolated renal tubules. Morphometric techniques are employed to assess structural consequences of chronic changes in transport function. Transport is assessed by tracer flux measurement and by electrophysiological methods. Of particular relevance to current problems in clinical nephrology, the mechanism by which protein feeding reduces the responsiveness of the tubuloglomerular feedback mechanism is under investigation.

PubMed Search for articles by faculty member

References

Okusa, M.D., Unwin, R.J., Velàzquez, H., Giebisch, G., and Wright, F.S. (1992) Active potassium absorption by the renal distal tubule. Am. J. Physiol. 262:F488-F493

Velàzquez, H., Perazella, M, Wright, F.S., and Ellison, D. (1993) Renal mechanism of trimethoprim-induced hyperkalemia. Ann Int. Med. 119:296-301