John Hayslett, M.D.

Professor of Medicine
Medical Director, Physicians Associate Program

B.A., 1956: College of the Holy Cross
M.D., 1960: Cornell School of Medicine
Residency: Yale-New Haven Hospital
Fellowship: Yale University

E-mail: john.hayslett@yale.edu


Epithelial cells in the distal portion of the nephron, large intestine, bronchial system, and alveoli exhibit a capacity of electrogenic sodium transport. This process involves diffusion of sodium ions into cells via highly selective sodium channels in the apical cell membrane. Recent studies in our laboratory show that a common signal transduction system mediates the action of multiple hormones that stimulate sodium transport. This process involves the increased turnover of phospholipids in the plasma membrane and release of calcium from intracellular stores. Our research focuses on determining the components of this system and the mechanism by which sodium channels are activated. It is hoped that a better understanding of sodium channel regulation will provide insights into channel dysfunction which causes some forms of hypertension and bronchial obstruction.

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References

Hayslett, J.P., Macala, L.J., Smallwood, J.I., Kalghatgi, L., Gasalla-Herraiz, J., Isales, C. (1995) Adenosine stimulation of Na transport is mediated by an A1 receptor and a [Ca]i-dependent mechanism. Kidney Int. 47:1576-1584

Rodriguez-Commes, J., Isales, C., Kalghatgi, L., Gassala-Herraiz, J., and Hayslett, J.P. (1994) Mechanism of insulin-stimulated electrogenic sodium transport. Kidney Int. 46:666-674