John Forrest, Jr., M.D.

Professor of Medicine
Director, Office of Student Research

B.S., 1960: Ursinus College
M.D., 1964: University of Pennsylvania
Residency: Yale-New Haven Hospital
Fellowship: Yale University

E-mail: john.forrest@yale.edu

The salt gland of the dogfish shark contains neuropeptide receptors and G-protein coupled receptors that regulate specific transport proteins (channels and carriers) in this species and higher vertebrates. Our laboratory is using molecular biological approaches to clone and sequence peptides (atrial natriuretic peptide, C-type natriuretic peptide) and transmembrane G-protein coupled receptors (adenosine and atrial natriuretic peptide receptors). Our goal is to use a primitive vertebrate (dogfish shark) to study the evolution and specific isoforms of these receptors and peptides in higher vertebrate epithelial tissues including the mammalian kidney. We are also defining the signal transduction pathways by which these receptors regulate transport proteins in both the rectal gland and mammalian nephron segments.

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References

Kelley, G.G., Poeschla, E.M., Barron, H.V., and Forrest, J.N., Jr. (1990) A1 adenosine receptors inhibit chloride transport in the shark rectal gland. Dissociation of inhibition and cyclic AMP. J. Clin. Invest. 85:1629-1636

Valentich, J.D. and Forrest, J.N., Jr. (1991) Cl-secretion by cultured shark rectal gland cells. I. Transepithelial transport. Am. J. Physiol. 260:C813-C823