Cecilia Canessa, M.D.
Associate Professor of Cellular and Molecular Physiology and Medicine

B.S., 1975: Cayetano Heredia College, Lima, Peru
M.D., 1982: Medical School Cayetano Heredia University, Lima, Peru
Residency: Henepin County Medical Center, University of Minnesota
Fellowship: University of Alabama

E-mail: Cecilia_Canessa@yale.edu


In my laboratory we are interested in studying structure-functional aspects of epithelial sodium channels. These proteins are members of a new family of ion channels with a novel structure that remains to be elucidated. The epithelial sodium channels play an important role in the maintenance of the extracellular volume and blood pressure thus their activity is regulated by many hormones and environmental factors. We are also working on various aspects of the functional regulation of these proteins.

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References

Canessa, C.M., Horisberger, J.D., Schild, L. and Rossier, B. (1995) Expression cloning of the epithelial sodium channel. Kid. Int. 48: 950-955

Canessa, C.M., Merillat, A.M. and Rossier, B. (1994) Membrane topology of the epithelial sodium channel alpha-subunit: identification of N-linked glycosylation sites and of start and stop transfer signals used in intact cell. Am. J. Physiol. 267: C1682-1690