Yale School of Medicine

Internal Medicine

NIDDK Inflammatory Bowel Disease Genetics Consortium, Digestive Diseases

NIDDK Inflammatory Bowel Disease Genetics Consortium, Digestive Diseases

Digestive Diseases
The Anlyan Center
300 Cedar Street, Room S160
PO Box 208019
New Haven CT 06520-8019
Tel: 203.785.6191
Fax: 203.785.7273

NIDDK Inflammatory Bowel Disease Genetics Consortium

Introduction and objectives

In 2002, the National Institute of Diabetes, Digestive and Kidney diseases (NIDDK) created an IBD Genetics Consortium consisting of six genetics research centers (GRCs) and a central data-coordinating center (DCC). The primary aim of this Consortium is to advance the discovery of genes influencing an individual’s risk for developing Crohn’s disease (CD) and ulcerative colitis (UC).

The current IBDGC specific aims include:

  1. Expansion, development and management of Consortium resources, including subject recruitment, phenotype data, and biospecimen collection,
  2. To employ a variety of approaches to identify genetic variation that contributes to IBD susceptibility,
  3. To build a risk model of IBD through understanding genetic influence on variations in phenotypic expressivity, gene pathway analysis, and gene-gene (G x G) and gene-environmental (G x E) interactions.

The six GRC’s are:

  1. Cedars-Sinai Genetics Research Center (CSGRC, PI: Kent D. Taylor, Ph.D.),
  2. Johns Hopkins Genetics Research Center (JHGRC, PI: Steven R. Brant, M.D.),
  3. University of Montreal Genetics Research Center (UMGRC, PI: John D. Rioux, Ph.D.),
  4. University of Pittsburgh Genetics Research Center (UPGRC, PI: Richard H. Duerr, M.D.),
  5. University of Toronto Genetics Research Center (UTGRC, PI: Mark S. Silverberg, M.D.),
  6. Yale University Genetics Research Center (YUGRC, PI: Judy H. Cho, M.D.).

The DCC is directed by Dr Cho and staffed by Anju Bhagwagar at Yale and Phil Schumm and Dr Nicolae at the University of Chicago.