John Concato, MD, MS, MPH Professor of Medicine Director, Clinical Epidemiology Research Center, VA Connecticut HealthCare System VA Connecticut Healthcare System 950 Campbell Avenue - 151B West Haven, CT 06516 Phone: (203) 932-5711 x 2993 Fax: (203) 937-4932 e-mail: john.concato@yale.edu

Training

B.E., 1980: The Cooper Union School of Engineering
M.S., 1981: New York University Graduate School of Arts and Science
M.D., 1985: New York University School of Medicine
M.P.H., 1991: Yale University School of Medicine
Residency: Bellevue Hospital - New York University Medical Center
Chief Residency: Bellevue Hospital - New York University Medical Center
Fellowship: Yale University School of Medicine, Robert Wood Johnson Clinical Scholars Program

Research Interests

As a general internist and clinical epidemiologist, I conduct research to address unanswered questions related to screening, prognosis, and treatment strategies, as well as to improve methods of research design and statistical analysis. This dual focus has involved a range of topics in both patient care and methodology; e.g., evaluating the effectiveness of medical interventions, identifying sources of bias in patient-oriented research, and assessing limitations of popular methods of statistical analysis.

Representative projects include evaluating the effectiveness of screening for prostate cancer, with corresponding refinement of observational methods for evaluating screening tests in general. Other projects have compared the results of observational studies and randomized trials, disputing prior claims of a simple “research design hierarchy.” Ongoing work involves studies of prognosis in prostate cancer, and clarifying the use of multivariable analysis in patient-oriented research.

Clinical Activities

Director, Medicine Based Evidence course for Yale medical students
Director, Clinical Research Seminars for Internal Medicine housestaff
Outpatient and Inpatient Physician, VA Connecticut HealthCare System

Selected Publications

1. Concato J, Horwitz RI, Feinstein AR, Elmore JG, Schiff SF. Problems of comorbidity in mortality after prostatectomy. JAMA 1992;267(8):1077-1082.
2. Concato J, Feinstein AR, Holford TR. The risk of determining risk with multivariable models. Ann Intern Med 1993;118:201-210.
3. Feinstein AR, Concato J. The quest for “power”: contradictory hypotheses and inflated sample sizes. J Clin Epidemiol 1998;51:537-545.
4. Bogardus ST, Concato J, Feinstein AR. Clinical epidemiological quality in molecular genetic research: the need for methodological standards. JAMA 1999;281:1919-1926.
5. Concato J. Prostate specific antigen: A useful screening test? Cancer J Sci Am 2000;6:S188-S192.
6. Concato J, Shah N, Horwitz RI. Randomized, controlled trials, observational studies, and the hierarchy of research designs. N Engl J Med 2000;342:1887-1892.
7. Concato J. Challenges in prognostic analysis. Cancer 2001;91:1607-1614.
8. Yaggi HK, Concato J, Kernan WN, Lichtman JH, Brass LM, Mohsenin V. Obstructive sleep apnea as a risk factor for stroke and death. N Engl J Med. 2005;353:2034-2041
9. Concato J, Wells CK, Horwitz RI, Penson D, Fincke G, Berlowitz DR, Froehlich G, Blake D, Vickers MA, Gehr GA, Raheb NH, Sullivan G, Peduzzi P. The effectiveness of screening for prostate cancer: A nested case-control study. Arch Intern Med. 2006;166:38-43.
10. Concato J, Jain D, Li WW, Risch HA, Uchio EM, Wells CK. Molecular markers and mortality in prostate cancer. BJU International (In press)