Adam V. Wisnewski, Ph.D.

Associate Professor of Medicine
Occupational & Environmental Medicine

Research Interests

Dr. Wisnewksi’s research is in the area of lung disease and allergy/immunology. His laboratory specializes in the leading chemical cause of occupational asthma (isocyanate), and has developed new blood tests for chemical hypersensitivity and exposure (click here for more information). Laboratory investigations include clinical discovery science-based studies as well as basic research on toxicology and cellular immune responses, in vitro and in vivo in animal models.

Current Research Projects

New Serodiagnostics for Isocyanate Exposure, A Major Cause of Occupational Asthma. A project funded by NIEHS (R41ES016728) to develop novel blood test into a format that can be readily used by clinical laboratories throughout the world.

SPRAY- A study of painters and repairers of autobodies at Yale is a multidisciplinary study, which involves in vitro laboratory studies on clinical samples obtained from workers exposed to isocyanate on the job.

Animal modeling of isocyanate asthma. In collaboration with dermatologist Dr. Christina Herrick, Associate Professor of Medicine at Yale, we are investigating fundamental mechanisms by which skin exposure leads to increased asthma pathology.

Education

B.S., University of California, Davis
Ph.D., Brown University
Post-doctoral Fellow, Harvard AIDS Institute
Post-doctoral Associate, Yale School of Medicine

Selected Publications

1. Wisnewski AV. Developments in laboratory diagnostics for isocyanate asthma. Curr Opin Allergy Clin Immunol 2007; 7:138-45.
2. Pronk A, Preller L, Raulf-Heimsoth M, Jonkers ICL, Lammers J-W, Wouters IM, Doeked G, Wisnewski AV, Heederik D. Respiratory symptoms, sensitization and exposure-response relationships in spray painters exposed to isocyanates. Am J Respir Cit Care Med 2007; 176:1090-97
3. Ye YM, Kim CW, Kim HR, Kim HM, Suh CH, Nahm DH, Park HS, Redlich CA, Wisnewski AV. Biophysical determinants of toluene diisocyanate antigenicity associated with exposure and asthma. J Allergy Clin Immunol 2006; 118:885-91.
4. Wisnewski AV, Stowe MH, Cartier A, Liu Q, Liu J, Chen L, Redlich CA. Isocyanate vapor induced antigenicity of human albumin. J Allergy Clin Immunol 2004 Jun;113:1178-84.
5. Wisnewski AV, Liu Q, Liu J, Chen L, and Redlich CA. Glutathione protects human airway epithelial cells and proteins against isocyanate Clin Exp Allergy 2005 35:352-7.
6. Wisnewski AV, Lemus R, Karol MH, Redlich CA. Isocyanate-conjugated lung epithelial cell proteins: “A link between exposure and asthma?” J Allergy Clin Immunol 104:341-347, 1999.Wisnewski AV, Srivastava R, Herrick C, Xu L, Lemus R, Cain H, Magoski NM, Karol MH, Bottomly K, and CA Redlich. Identification of human lung and skin proteins conjugated with hexamethylene diisocyanate in vitro and in vivo. Am J Respir Crit Care Med 162:2330-2336, 2000.

E-mail
adam.wisnewski@yale.edu

Office Phone
(203) 737-2544

Lab Phone
(203) 737-4054

Fax
(203) 785-3826