Richard E. Sutton, M.D., Ph.D.

Section of Infectious Diseases
Associate Professor of Medicine

Clinical Interests

HIV and general infectious diseases

Research Interests

Our laboratory is focused on the study of human immunodeficiency virus type I (HIV) replication and the development of small animal models of HIV. For example, mice are not susceptible to HIV due a profound block in HIV assembly and release from cells. We are exploring the nature of this block and are conducting genetic screens to identify human genes that may be able to overcome this deficiency. This has led to an innovative method of making nested intrachromosomal deletions, which could be used to identify previously unknown tumor suppressors and genes involved in developmental defects. We also utilize replication-defective HIV as a vector to transduce non-dividing cells for gene therapeutic purposes and are developing novel methods of vector production. These vectors are used to investigate other viruses (for example, cellular binding and entry requirements of Ebola and Western Equine Encephalitis) and to explore fundamental questions in molecular biology, such as the fidelity of RNA polymerase II.

Recent Publications

• Poluri, A, & Sutton, RE. Functional pseudotyping of western equine encephalitis virus glycoprotein with human immunodeficiency virus type 1 vectors, submitted.
• Poluri, A, & Sutton, RE. Reduction in titer of shRNA-encoding HIV vectors by a DICER-dependent mechanism. Mol. Ther. 16:378-86, 2008.
• Coskun, AK, van Maanen, M, Janka, D, Stockton, D, Stankiewicz, P, Yatsenko, S, & Sutton, RE. Isolation and characterization of mouse-human microcell hybrid cell clones permissive for infectious HIV particle release. Virology 362:283-93, 2007.
• Baliga, C, van Maanen, M, Chastain, M, & Sutton, RE. Vaccination of mice with replication-defective human immunodeficiency virus induces cellular and humoral immunity and protects against vaccinia virus-gag challenge. Mol. Ther. 14: 432-441, 2006.
• Coskun, AK, van Maanen, M, Nguyen, V, & Sutton, RE. Human chromosome 2 carries a gene required for production of infectious human immunodeficiency virus type 1. J. Virol. 80: 3406-3415, 2006.

Contact

Campus Address
300 Cedar Street
TAC S210

E-mail
richard.sutton@yale.edu

Office Phone
(203) 737-3648

Lab Phone
(203) 737-3632

Fax
(203) 785-6815