Albert J. Sinusas

Professor of Medicine and Diagnostic Radiology
Director, Animal Research Laboratories, Section of Cardiovascular Medicine
Director, Cardiovascular Nuclear Imaging & Stress Laboratories
Section of Cardiovascular Medicine

Clinical Interests

Cardiovascular imaging, stress testing, ischemic heart disease

Research Interests

Advanced cardiovascular and molecular imaging

My research is directed at development of noninvasive imaging approaches for the assessment of myocardial viability, angiogenesis, and post–infarction remodeling. This translational research employs the 3–D modalities of SPECT, PET, echocardiography and MR imaging for assessment of regional myocardial perfusion, function and metabolism, in an animal physiology laboratory, employing large and small animal models of myocardial ischemia and infarction, and peripheral arterial disease. My laboratory is currently focused on targeted molecular imaging, developing non–invasive nuclear imaging strategies for identifying the hypoxic stimulus for angiogenesis, and targeted imaging of selected integrins previously established to modulate the angiogenic process, and evaluation of the role of matrix metalloproteinases on post–infarction remodeling. The investigation of these biological processes involves, in vitro cellular and whole heart preparations, as well as ex vivo and in vivo imaging in both small and large animal models, using dedicated high–resolution and real–time 3D ultrasound imaging, hybrid SPECT–CT and PET–CT imaging, cardiac MR imaging, and fluorescent imaging systems.

Selected Publications

• Zhu Q, Piao D, Sadeghi MM, Sinusas AJ. Simultaneous optical coherence tomography imaging and beta particle detection. Optical Letters 28:1704-1706 2003
• Meoli DF, Sadeghi MM, Krassilnikova S, Bourke BN, Giordano FG, Dione DP, Su H, Edwards DS, Liu S, Harris TD, Madri JA, Zaret BL, Sinusas AJ. Non-invasive imaging of myocardial angiogenesis following experimental myocardial infarction. J Clin Invest 113:1684-1691, 2004
• Hua J, Dobrucki L, Sadeghi M, Zhang J, Bourke B, Cavaliere P, Song J, Chow C, Jahanshad N, vanRoyen N, Buschmann I, Madri J, Mendizabal M, Sinusas AJ. Noninvasive imaging of angiogenesis with a 99mTc-labeled peptide targeted at alpha-v beta-3 integrin following murine hindlimb ischemia. Circ. 111:3255-60, 2005
• Su H, Spinale FG, Dobrucki LW, Song J, Hua J, Sweterlitsch S, Dione DP, Cavaliere P, Chow C, Bourke BN, Hu X, Azure M, Yalamanchili P, Liu R, Cheesman EH, Robinson S, Edwards DS, Sinusas AJ. Non-nvasive Targeted Imaging of Matrix Metalloproteinase Activation in a Murine Model of Post-Infarct Remodeling. Circulation 112:3157-3167, 2005
• Lindsey ML, Escobar GP, Dobrucki WL, Goshorn DK, Bouges S, Mingoia JT, McClister DM, Jr., Su H, Gannon J, MacGillivray C, Lee RT, Sinusas AJ, Spinale FG. Matrix Metalloproteinase-9 Gene Deletion Facilitates Angiogenesis Following Myocardial Infarction. Am J Physiol:Heart & Circ Phys 290:232-9 2006
• Yan P, Sinusas AJ, Duncan JS. Boundary element method-based regularization for recovering of LV deformation. Med Image Anal. 2007
Gropler RJ, Glover DK, Sinusas AJ, Taegtmeyer H. (Eds), Cardiovascular Molecular Imaging,; Informa Healthcare, New York, NY ( 2007)

Education:	B.S., Rensselaer Polytechnic Institute, 1979 M.D., University of Vermont, 1983
Training:	Internship & Residency: University of Oklahoma, 1983 Cardiology Fellowship: University of Virginia, 1986
Prior Academic Training:	Assistant Professor: Medicine, Yale University, 1992 Associate Professor: Medicine, Yale University, 1998

Contact

Campus Address
Department of Internal Medicine
Section of Cardiovascular Medicine
Yale University
School of Medicine
Box 208017
New Haven, CT
06520-8017

E-mail
albert.sinusas@yale.edu

Telephone
203.785.4114