Jonathan M. Siner M.D.

Assistant Professor
Pulmonary and Critical Care Medicine

Medical Director
Medical Stepdown Unit - Yale-New Haven Hospital

Educational Background

Undergraduate: Swarthmore College, Swarthmore PA.
Medical School: University of Pittsburgh School of Medicine, Pittsburgh, PA.
Residency: Hospital of the University of Pennsylvania, Philadelphia PA.
Fellowship: Pulmonary and Critical Care Medicine
Yale University School of Medicine, New Haven CT.

Clinical Interests

• Critical Care
• Acute Respiratory Distress Syndrome (ARDS)
• Sepsis Syndrome
• Interstitial Lung Diseases

Research Interests

Dr. Siner currently conducts translational research examining the role of circulating growth factors in the sepsis syndrome and their relationship to outcomes in the intensive care unit. Patients with a diagnosis of sepsis are enrolled from the Medical Care Intensive Care Unit at Yale-New Haven Hospital. Plasma and DNA specimens are obtained and extensive clinical data is abstracted and entered into a clinical database. These investigations drawn on the extensive basic science activity conducted in the Pulmonary Section and examine these discoveries in humans with sepsis and ARDS. He has recently completed an investigation using a transgenic mouse model to examine the role of Vascular Endothelial Growth Factor (VEGF) induction of Heme Oxygenase-1 (HO-1) in protecting the lung from hyperoxic acute lung injury. He was the recipient of an NIH National Research Service Award which supported this project. He is a site co-investigator on several ongoing multi-center trials including an NIH sponsored study investigating the role of recombinant activated protein C in Acute Respiratory Distress Syndrome and an industry sponsored Phase II/III study of a novel treatment for severe sepsis. He also participates in the many active clinical trials being conducted by the Interstitial Lung Disease program.

Publications

Siner JM, Jiang G, Cohen ZI, Shan P, Zhang X, Lee CG, Elias JA, Lee PJ. VEGF-induced Heme Oxygenase-1 confers cytoprotection in lethal hyperoxic acute lung injury in vivo. FASEB Journal (in press).

Contact

Campus Address
Department of Internal Medicine
P.O. Box 208057
New Haven, CT 06520-8057

E-mail
jonathan.siner@yale.edu

Phone
203-785-3627

Fax
203-785-3826

Appointments
203-785-4198