Mark D. Siegel, M.D.

Associate Professor

Educational Background

Medical School: Columbia University, College of Physicians & Surgeons
Residency: Hospital of the University of Pennsylvania, Internal Medicine, 1991
Fellowship: Yale School of Medicine, Pulmonary and Critical Care Medicine

Clinical Interests

Life threating asthma, sepsis, acute lung injury.

Research Interests

Dr. Mark Siegel, the director of the Y-NHH MICU, is involved in multiple clinical research studies. For several years he has participated in multicenter clinical research trials investigating new treatments for sepsis and acute respiratory distress syndrome (ARDS), in addition to other facets of critical illness. He participated in all phases of the development of Drotrecogin alpha (activated), now marketed as Xigris, which has been shown to significantly decrease mortality among patients with severe sepsis. Dr. Siegel has several ongoing research projects conducted with Yale medical students, housestaff, and fellows, in areas such as the management of sepsis, end-of-life decision making, and psychiatric disorders in the next-of-kin of ICU patients. His major focus currently is a translational project examining the pathogenesis of sepsis and ARDS, conducted in conjunction with Drs. Elias and Siner.

Representative Publications

Siegel, M.D. Management of Agitation in the Intensive Care Unit. Clinics in Chest Medicine 24:713-725, 2003.

Goldberg PA, Siegel MD, Sherwin RS, Halickman JI, Lee M, Bailey VA, Lee SL, Dziura JD, Inzucchi SE. Implementation of a Safe and Effective Insulin Infusion Protocol in a Medical Intensive Care Unit. Diabetes Care 27: 461-467, 2004

Goldberg PA, Siegel MD, Russell RR, Sherwin RS, Halickman JI, Cooper DA, Dziura JD, Inzucchi SE. Experience with the Continuous Glucose Monitoring
System® in a Medical Intensive Care Unit. DIABETES TECHNOLOGY & THERAPEUTICS 2004; 6:339-347

Siegel MD. Applying the Evidence: Multiple Urgent Therapies for Patients with Sepsis. Crit Care Med 2006; 34:1264-1265

Siegel MD, Kimmel R. A 48-year-old Woman with Pneumonia, Shock, and a Rash. Chest 2006; 129:1724-1727

Siegel, MD. Alone at the Life's End: Trying to Protect the Autonomy of Patients without Surrogates or Decision-Making Capacity. Crit Care Med. 2006; 34:2238-2239

Siegel, MD. Dismantling the Barriers to Optimal End-of-Life Care in the ICU. Crit Care Med 2006; 34:2679-2680.

Contact

Campus Address
Department of Internal Medicine
P.O. Box 208057
New Haven, CT 06520-8057

E-mail
mark.siegel@yale.edu

Phone
203-737-1672

Fax
203-688-1188

Appointments
203-785-4198