Henry M. Rinder, M.D.

Associate Professor of Laboratory Medicine and Internal Medicine
Director, Hematology Laboratories
Director, Clinical Pathology Residency Training

Research Activities

Dr. Rinder's research interests primarily revolve around cellular coagulation and platelet physiology in two related areas. First, the laboratory investigates the biology of platelet activation and subsequent leukocyte-platelet adhesive interactions. Our laboratory has investigated the responsible receptor-ligand pairs, the adhesive alterations as a result of signal transduction, and differences in functional cell adhesion based on cell lineage and phenotype. This bench investigation has led the laboratory into studying the mechanisms of platelet and leukocyte activation during platelet storage and in the setting of extracorporeal circulation. During extracorporeal circulation, the complement system plays a major role in stimulating cellular events and this, in turn, has led to investigations of specific complement component blockade.

Clinical and Teaching Activities

Dr. Rinder sees adult hematology/oncology patients and carries out pathology interpretative clinical work through the Yale Faculty Practice. Dr. Rinder is actively involved in teaching at the graduate level through the Laboratory Medicine and Hematology teaching programs at the Yale School of Medicine. Dr. Rinder also teaches residents, fellows, postdoctoral and graduate students and at continuing education courses organized through the Yale Cancer Center, and the Departments of Internal Medicine and Laboratory Medicine.

Education

M.D., University of Vermont College of Medicine, 1984

B.S., Yale College, 1979

Residencies and Fellowships: Maine Medical Center, Portland, ME; Yale University and Yale-New Haven Hospital, New Haven, CT

Community of Science Biosketch

Selected Publications

• Kosten TR, Tucker K, Gottschalk PC, Rinder CS, Rinder HM. Platelet Abnormalities Associated with Cerebral Perfusion Defects in Cocaine Dependence. Biol Psychiatry 2004;55:91-97
• Greilich PE, Brouse CF, Rinder CS, Smith BR, Sandoval BA, Rinder HM, Eberhart RC, Jessen ME. Effects of -Aminocaproic Acid and Aprotinin on Leukocyte-Platelet Adhesion in Patients Undergoing Cardiac Surgery. Anesthesiology 2004;100:225-33
• Patel PB, Pfau SE, Cleman MW, Brennan JJ, Howes C, Remetz M, Cabin HS, Setaro JF, Rinder HM. Comparison of coronary artery specific leukocyteplatelet conjugate formation in unstable versus stable angina pectoris. Am J Cardiol 2004;93: 410-413
• Angelopoulou MK, Rinder H, Wang C, Burtness B, Cooper DL, Krause DS. A preclinical xenotransplantation animal model to assess human hematopoietic stem cell engraftment. Transfusion. 2004;44(4):555-66
• Fontes ML, Mathew JP, Rinder HM, Zelterman D, Smith BR, Rinder CS. Atrial fibrillation after cardiac surgery/cardiopulmonary bypass is associated with monocyte activation. Anesthesia and Analgesia 2005;101(1):17-23
• Ernst LM, Crouch J, Rinder HM, Howe JG. Bacterial Etiology for Chronic Villitis is not supported by Polymerase chain reaction for 16S rRNA DNA. Pediatric and Developmental Pathology 2005;8(6):647-53
• Mathew JP, Rinder HM, Smith BR, Newman MF, Rinder CS. Transcerebral Platelet Activation after Aortic Cross-Clamp Release is Linked to Neurocognitive Decline. Ann Thorac Surg 2006;81:1644-1649
• Rinder CS, Rinder HM, Smith MJ, Fitch JCK, Tracey JB, Chandler WL, Rollins SA, Smith BR. Antithrombin reduces monocyte and neutrophil CD11b upregulation in addition to blocking platelet activation during extracorporeal circulation. Transfusion 2006;46:1130-1137
• Smith BR, Wells A, Alexander CB, Bovill E, Campbell S, Dasgupta A, Fung M, Haller B, Howe JG, Parvin C, Peerschke E, Rinder HM, Spitalnik S, Weiss R, Wener M for the Academy of Clinical Laboratory Physicians and Scientists. Curriculum Content and Evaluation of Resident Competency in Clinical Pathology (Laboratory Medicine): a Proposal. Human Pathology 2006;37:934-968
• Rinder CS, Smith MJ, Rinder HM, Krause JE, Cortright DN, Brodbeck RM, Smith BR. Leukocyte effects of C5a receptor blockade during simulated extracorporeal circulation. Annals of Thoracic Surgery 2007;83(1):146-52
• Tang YD, Rinder HM, Katz SD. Effects of Recombinant Human Erythropoietin on Antiplatelet Action of Aspirin and Clopidogrel in Healthy Subjects: Results of a Double-Blind, Placebo-Controlled Randomized Trial. American Heart J 2007;154(3):494.e1-7
• Bhandari V, Wang C, Rinder CS, Rinder HM. Hematologic Profile of sepsis in neonates: neutrophil CD64 as a diagnostic marker. Pediatrics 2008;121:129-134
• Kenney BC, Zieske A, Rinder HM, Smith BR. DNA Ploidy Analysis as an Adjunct for the Detection of Relapse in B-Lineage Acute Lymphoblastic Leukemia. Leukemia & Lymphoma 2008;49:42-48

The laboratory accepts graduate students directly through the Yale Program in Biomedical Engineering or as an adjunct laboratory through the Graduate School Combined Programs in Biological and Biomedical Sciences. Post-doctoral fellows (MD, PhD or MD/PhD) are also accepted, most commonly through the Departments of Laboratory Medicine, Pathology, Internal Medicine/Hematology, Internal Medicine/Oncology, Anesthesiology, Pediatrics/Hematology-Oncology, or Pediatrics/Infectious Diseases. Yale medical students may elect to work in the laboratory through the standard thesis mechanism and Yale undergraduate students may apply through the Molecular Biochemistry and Biophysics course 470a and 471b. To e-mail Dr. Rinder, please click here.

Contact

Campus Address
Fitkin 617

E-mail
henry.rinder@yale.edu

Office Phone
(203) 688-8176

Fax
(203) 688-4111