Mark Perazella

Associate Professor of Medicine
Director, Nephrology Fellowship Training Program
Director, Acute Dialysis Unit
Medical Director, Yale Physician Associate Program
Section of Nephrology

Clinical Interests

Consultative Nephrology

• Acute kidney inury (AKI)
• Chronic kidney disease
• Critical Care Nephrology
• HIV-related Kidney Disease
• End Stage Renal Disease

Research Interests

1. Diagnostic utility of urine microscopy in AKI
   
   • Urine sediment utility in distinguishing ATN from prerenal azotemia
   • Prognostic value of the urine sediment in predicting AKI severity
2. Adverse renal effects of therapeutic agents and other drugs
3. Hypotension in ESRD patients during Hemodialysis
   
   • Role of vasopressin deficiency in intradialytic hypotension (IDH)
   • Utility of midodrine in treatment of IDH
   • Potential utility of vasopressin in the treatment of IDH
4. HIV-related kidney disease
   
   • Diagnosis and management with HAART
   • Nephrotoxicity of therapeutic agents (HAART)
5. Nephrogenic systemic fibrosis
   
   • Treatment with sodium thiosulfate

PubMed Search for articles by faculty member

Selected Recent Publications

• Cruz DN, Perazella MA, Bellomo R, Polanco N, de Cal M, Corradi V, Nalesso F, Lentini P, Ueno T, Ranieri VM, Ronco C: Effectiveness of polymyxin B-immobilized fiber column in sepsis: a systematic review. Crit Care 2007;11(2): 1-12.
• Seidner MA, Atta MG, Perazella MA, Lucas GM, Fine DM: Poor validity of urine dipstick as a screening tool for proteinuria in HIV patients. J Acquir Immune Defic Syndr 2008;47(2):261-263.
• Rho M, Perazella MA, Parikh CR, Peixoto A, Brewster UC: Serum vasopressin response in patients with intradialytic hypotension: A pilot study. Clin J Am Soc Nephrol 2008;3(3):729-35.
• Perazella MA, Coca SG, Brewster UC, Kanbay M, Parikh CR: The diagnostic value of urine microscopy for differential diagnosis of acute kidney injury in hospitalized patients. Clin J Am Soc Nephrol 2008; 3(6):1615-9.
• Kadiyala D, Roer D, Perazella MA: Nephrogenic systemic fibrosis associated with gadoversetamide exposure: Treatment with sodium thiosulfate. 53(1):133-7, 2009
• Fine DM, Perazella MA, Lucas GM, Atta MG: Kidney Biopsy in HIV: Beyond HIVAN. Am J Kidney Dis 2008;51(3):504-514.
• Perazella MA: Tissue deposition of gadolinium and development of NSF: A convergence of factors. Seminars Dialysis 2008;21(2):150-4.
• Perazella MA: Nephrogenic systemic fibrosis and gadolinium-based contrast: What’s a nephrologist to do? Seminars Dialysis 2008;21(2):121-2.
• Yarlagadda S, Perazella MA: Drug-induced crystal nephropathy: An update. Expert Opin Drug Safety 2008;7(2):147-58.
• Fine DM, Perazella MA, Lucas GM, Atta MG: Renal disease in HIV infection: epidemiology, pathogenesis and management. Drugs 2008;68(7):963-80.
• Coca SG, Perazella MA: Early treatment of drug-induced acute interstitial nephritis with steroids following withdrawal of offending agent enhances renal recovery and reduces risk for chronic kidney disease. Nat Clin Pract Nephrol 2008;4:298-9.
• Perazella MA: How should nephrologists approach gadolinium-based contrast imaging in patients with kidney disease? Clin J Am Soc Nephrol 2008;3(3):649-51.
• HYPERLINK "http://www.ncbi.nlm.nih.gov/pubmed/18609504?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum" Cruz DN, Perazella MA, Ronco C. The role of extracorporeal blood purification therapies in the prevention of radiocontrast-induced nephropathy. Int J Artif Organs. 2008;31(6):515-24.
• Brewster UC, Perazella MA: Proton pump inhibitors: Acute interstitial nephritis and other renal effects. In: DeBroe M, Porter G eds. Clinical Nephrotoxins–Renal Injury from Drugs and Chemicals. pp. 567-578, 2008, 3rd Edition
• Perazella MA: Gadolinium-contrast toxicity in patients with kidney disease: nephrotoxicity and nephrogenic systemic fibrosis. Curr Drug Saf. 2008 3(1):67-75.
• Brewster UC, Perazella MA: Proton pump inhibitors: Acute interstitial nephritis and other renal effects. In: DeBroe M, Porter G eds. Clinical Nephrotoxins–Renal Injury from Drugs and Chemicals. pp. 567-578, 2008, 3rd Edition
• Perazella MA, Markowitz GS: Bisphosphonate nephrotoxicity. Kidney Int 2008;74(11):1385-93.

Education:	M.D., 1988: New York Medical College
Training:	Residency: St. Mary’s Hospital/ Yale Primary Care Program Fellowship: Yale University

Contact

Campus Address
Section of Nephrology
Department of
Internal Medicine
Yale School of Medicine
P.O. Box 208029
New Haven, CT
06520–8029

E-mail
mark.perazella@yale.edu