Chun Geun Lee, M.D., Ph.D.

Assistant Professor

Educational Background

Medical School: Hanyang University School of Medicine, Seoul Korea

M.M. Sc/Ph.D.,: Genetics, Hanyang University , Seoul Korea

Fellowship: National Institute of Health(NIH), Yale University School of Medicine

Research Interest

• Generation and characterization of lung-specific transgenic mice for asthma and pulmonary fibrosis study
• Vascualr Endothelial Growth Factor(VEGF) in the lung: relation to airway response, remodeling and asthma pathogenesis
• Molecular mechanism of Chronic Obstructive Lung Disease(COPD; Emphysema)

Representative Publications

C.G. Lee, H.C. Morse III, B.K. Kay and C.A. Kozak : Genetic mapping of eight SH3 domain genes on seven mouse chromosomes. Mammalian Genome, 10(4):402-404, 1999.

Lee C.G., H.J. Yoon, Z. Zhou, H. Link, Z. Wang, J.M. Gwaltney Jr., M. Landry and J.A. Elias. Respiratory syncytial virus stimulation of vascular endothelial cell growth factor/ vascular permeability factor (VEGF/VPF). Am. J. Respir. Cell Mol. Biol 23:662-669, 2000.

Lee C.G. R.J. Homer , Z. Zhu, S. Lanone, X. Wang, V. Koteliansky, P. Noble, Q. Chen, R. Senior and J.A. Elias. Interleukin-13 induces tissue fibrosis by selectively stimulating and activating TGF-b1. J Exp Med 194:809-821, 2001.

Lee C.G., R.J. Homer, L. Cohn, H. Link, S.S. Jung, J.E. Craft, B.S. Graham, T.R. Johnson, and J.A. Elias. Transgenic expression of IL-10 in the lung causes mucus metaplasia, tissue inflammation and airways remodeling via IL-13-dependent and -independent pathways. J Biol Chem 277(38):35466-35474, 2002.

Lee C.G., Cho S.J., Kang M.J., Chapoval S.P., Lee P.J., Noble P.W., Yehualaeshet T., Lu B., Flavell R.A., Milbrandt J., Homer R.J., Elias J.A.. Early Growth Response Gene 1-mediated Apoptosis Is Essential for Transforming Growth Factor-b1-induced Pulmonary Fibrosis. J Exp Med 200(3):377-389, 2004.

Lee C.G., Link H., Baluk P., Homer R.J., Chapoval S., Bhandari V., Kang M.J., Cohn L., Kim Y.K., McDonald D.M., Elias J.A.. Vascular Endothelial Growth Factor (VEGF) Induces Remodeling and Enhances T h2 Sensitization and Inflammation in the Lung. Nature Medicine 10:1095-1193, 2004.

Elias J.A., Lee C.G. Lipid let loose in pulmonary emphysema. Nature Medicine 11(5):471-2, 2005

Cho SJ, Kang MJ, Homer RJ, Kang HR, Zhang X, Lee PJ, Elias JA, Lee CG. Role of early growth response-1 (Egr-1) in IL-13-induced inflammation and remodeling. J Biol Chem. 281(12):8161-8, 2006.

Bhandari V, Choo-Wing R, Chapoval SP, Lee CG, Tang C, Kim YK, Ma B, Baluk P, Lin MI, McDonald DM, Homer RJ, Sessa WC, Elias JA. Essential role of nitric oxide in VEGF-induced, asthma-like angiogenic, inflammatory, mucus, and physiologic responses in the lung. Proc Natl Acad Sci U S A. 18;103(29):11021-6, 2006.

Bhandari, V., Choo-Wing, R., Lee, C.G., Zhu, Z., Nedrelow, J. H., Chupp, G.L., Matthay,M.A., Homer, R.J., Elias, J.A. Hyperoxia causes angiopoietin-2-mediated acute lung injury and necrotic cell death. Nature Medicine 2006;12(11):1286-93

Lee C.G. and Elias JA. Transgenic Models. In Encyclopedia of Respiratory Medicine, Elsevier eds: Laurent GL and Shapiro S, pp. 283-287, 2006

Contact

Campus Address
Department of Internal Medicine
P.O. Box 208057
New Haven, CT 06520-8057

E-mail
chungeun.lee@yale.edu

Phone
203-737-1232

Fax
203-785-3826