Michael Kozal, M.D.

Associate Professor of Medicine
Yale AIDS Program & Acting Chief of Infectious Disease, VA CT

Research Interests

Dr. Kozal's major research interests are investigations into the viral genetic determinants of drug resistance development for both HIV and Hepatitis C. Dr. Kozal's lab uses DNA microarrays and Ultra Deep sequencing technologies to detect minority drug resistant viral populations in patients to determine the impact of that minor viral populations have on clinical outcomes. In addition, Dr. Kozal is the principal investigator on multiple HIV clinical trials that investigate new antiretroviral agents.

Recent Publications

• Lataillade M, Chiarella J, and Kozal MJ. Natural Polymorphism of the HIV-1 Integrase gene. In press, Antiviral Therapy, 2007.
• Braithwaite RS, Kozal MJ, Chang CH, et al. Adherence, Virologic Responses and Immunologic Outcomes for HIV+ Veterans Starting Combination Antiretroviral Therapies. In press, AIDS 2007.
• MacArthur RD, Novak RM, Peng G, Chen L, Xiang Y, Huppler Hullsiek K, Kozal MJ, et al. Long-Term Clinical and Immunologic Outcomes Are Similar in HIV-Infected Persons Randomized to NNRTI versus PI versus NNRTI+PI-based Antiretroviral Regimens as Initial Therapy: Results of the CPCRA 058 FIRST Study. Lancet 2006;368:2125-35.
• Kozal MJ, Amico KR, Chiarella J, et al. A Population Based and Longitudinal Study of Sexual Behavior and Multidrug Resistant HIV Among Patients in Clinical Care. MedGenMed. 2006 Jun 13;8(2):72-82.
• Kozal MJ, Huppler Hullsiek K, Leduc R, et al. Prevalence and Impact of HIV-1 Protease Codon 33 Mutations and Polymorphisms in Treatment-Naïve and Treatment-Experienced Patients Enrolling in Clinical Trials. Antiviral Therapy 2006;11(4):457-463.
• Lataillade M, Kozal MJ. The Hunt for HIV-1 Integrase Inhibitors. AIDS Patient Care and STD 2006; 20(7): 489-501.
• Kozal MJ, Amico KR, Chiarella J, Cornman D, Fisher W, Fisher J, Friedland G. HIV Drug Resistance and HIV Transmission Risk Behaviors in Injection Drug Users. Journal of Acquired Immune Deficiency Syndrome 2005;40(1):106-109.
• Novak RM, Chen L, MacArthur RD, Baxter J, Huppler Hullsiek K, Peng G, Xiang Y, Henley C, Schmetter B, Uy J, van den Berg-Wolf and Kozal M for the CPCRA 058 Study Team. Prevalence of Antiretroviral Drug Resistance Mutations in Chronically HIV-Infected, Treatment Naïve Participants in the CPCRA FIRST Study: Implications for Routine Resistance Screening Prior to Initiating Antiretroviral Therapy. Clinical Infectious Diseases 2005;40(3):468-74.
• Kozal MJ, Amico KR, Chiarella J, Schreibman T, Cornman D, Fisher W, Fisher J, Friedland G. Antiretroviral resistance and high-risk transmission behavior among HIV+ patients in clinical care. AIDS 2004; 18:2185-2189.
• Kozal MJ. Cross-resistance patterns among HIV-1 protease inhibitors. AIDS Patient Care and STD 2004 Vol 18 # 4; 199-208.
• MacArthur RD, Chen L, Peng G, Novak RM, van den Berg-Wolf M, Kozal M, et al. Efficacy and Safety of ABC+3TC versus ddI+d4T in AR-Naïve persons on their FIRST HAART regimen: the NRTI substudy of the CPCRA 058 FIRST Study. HIV Clinical Trials 2004;5(6):361-70.
• Kozal MJ, Shah N, Shen N, Yang R, Fucini R, Merigan TC, Richman DD, Chee M, Gingeras TR. Extensive polymorphism observed in HIV-1 clade B protease gene using high density oligonucleotide arrays: implication for therapy. Nature Medicine 1996;2:753-8.
• Shapiro JM, Winters MA, Kozal MJ, Merigan TC. Saquinavir monotherapy trial: prolonged suppression of viral load and resistance mutations with higher dosage. Annals of Internal Medicine 1996;124:1039-1050.
• Lipshutz RJ, Morris D, Chee M, Hubbell E, Kozal MJ, Shah N, Shen N, Yang R, Fodor SPA. Using oligonucleotide probe arrays to access genetic diversity. Biotechniques 1995;19:442-447.
• Kozal MJ, Kroodsma K, Winters MA, Katzenstein DA, Halpern J, Merigan TC. Development of a didanosine (ddI) resistance mutation in 64 HIV-infected patients switched from zidovudine (ZDV) to ddI monotherapy: relationship to CD4+ T cell changes and virus burden. Annals of Internal Medicine 1994;121:253-268.

Contact

Campus Address
135 College Street
Suite 323

E-mail
michael.kozal@yale.edu

Office Phone
(203) 688-2685

Fax
(203) 937-3476