Avlin Imaeda, M.D.

Assistant Professor
Section of Digestive Diseases

Clinical Interests

General Gastroenterology and Diseases of the small bowel

Most of my time is spent in clinical practice at the West Haven Veterans Administration Hospital. I teach GI fellows basic endoscopy techniques and help supervise fellows in the VA GI clinic and on the consult service. I organize the fellow's Friday lecture series and the Yale Physician's Assistant Digestive Physiology and Disease course. Additionally, I read small bowel capsules and perform double balloon endoscopy. This is a new technique which has the potential to allow endoscopic evaluation and treatment of the entire small bowel.

Research Interests

protective effects of low dose aspirin in liver disease, patient preferences and barriers to patient's seeking colonoscopic screening.

I have been involved in a project with Wajahat Mehal evaluating protective effects of aspirin in mouse models of liver disease and we have identified a previously unknown anti-inflammatory mechanism for aspirin. We are seeking support to initiate a small clinical trial to see whether low dose aspirin is protective in human liver disease.

I am beginning a project to evaluate patient preferences for different modes of colon cancer screening. I would like to compare colonoscopy, CT colonography and colon capsule endoscopy in hopes that we can better understand patient preferences and barriers to patients seeking colon cancer screening.

Selected Publications

• Imaeda, A., Sutterwala, F., Watanabe, A., Mahmood, S., Sohail, M., Flavell, R., Mehal, W. (2007, manuscript submitted) Acetaminophen induced hepatotoxicity is dependent on the NALP3 inflammasome and can be inhibited by aspirin.
• Longacre, A., Imaeda, A., Garcia-Tsao, G., Fraenkel, L. (2007) A pilot project examining the predicted preferences of patients an dphysicians in the primary prophylaxis of variceal hemorrhage. Hepatology (published online Oct 12)
• Rodes, J., Benhamou, J-P., Blei, A., Reichen, J., Rizzetto, M. ed Textbook of Hepatology. Blackwell Publishing (2007). “Chap 2.7.3 Antibody Production and Transport in the Liver.” Imaeda, A, Mehal, W. pp325-332
• Smith, D.S., Sullivan, L.E., Hay, S.F. ed. Field Guide to Internal Medicine. Lippincott, Williams & Wilkins 2005. “Chap 5 Infectious Diarrhea.” Imaeda, A.B.
• Smith, D.S., Sullivan, L.E., Hay, S.F. ed. Field Guide to Internal Medicine. Lippincott Williams & Wilkins 2005. “Chap 69 Gastric Cancer.” Imaeda, A.B.
• Barlow, A.K., He, X., Janeway, C., Jr. (1998) Exogenously provided peptides of a self- antigen can be processed into forms that are recognized by self-T cells. J. Exp. Med. 187:1403- 15.
• Barlow, A.K., Like, A.A. (1992) Anti-CD2 monoclonal antibodies prevent spontaneous and adoptive transfer of diabetes in the BB/Wor Rat. Amer. J. of Path. 141:1043-51.

Office Phone
(203) 932-5711 ext 5339