Erica Herzog M.D., Ph.D.

Assistant Professor, Internal Medicine/Pulmonary Critical Care Lecturer, Molecular Biophysics and Biochemistry

Research Interests

Bone marrow progenitor cells have shown a surprising ability to repopulate cells of many nonhematopoietic organs including the lung. This finding has implications for novel therapeutic approaches to both inherited and acquired disorders of the respiratory tract. Using murine models, Dr. Herzog's research focuses on defining the phenotype of bone marrow derived pneumocytes in a number of disease states including surfactant deficiencies. Another focus of this work utilizes Cre-lox technology to define the mechanism by which marrow derived cells adopt an epithelial phenotype in the adult murine lung and the use of these mechanisms for nuclear reprogramming and cytotherapy. The overall goal of these pursuits is to define a functional role for bone marrow in the treatment of murine models of human lung disease. To date, Dr. Herzog has been supported by grants from the Parker B. Francis Foundation, and the Yale Center for Excellence in Molecular Hematology, as well as by a Career Development Award (K08) from the NIH.

Publications

Herzog EL, Hu BQ, VanArnam JS, Krause DS. Threshold of Injury Required for the Appearance of Bone Marrow Derived Lung Epithelium. Stem Cells, 2006, in press.

VanArnam JS, Herzog EL, Grove JE, Bruscia ES, Krause DS. Stem Cell Plasticity. Stem Cell Reviews, 2005.

Borue X., Lee S, Grove J, Herzog EL, Harris RG, Diflo T, Glusac E, Hyman K, Theise ND, Krause DS. Bone Marrow-Derived Cells Contribute to Epithelial Engraftment during Wound Healing. Am J Pathol 2004 165(5): 1767-72.

Herzog EL. "Multipotent Adult Progenitor Cells", in Handbook of Cytotherapy. Edward L. Snyder, editor, American Association of Blood Banks, Bethesda MD, 2004.

Harris RG*, Herzog EL*, Grove JE, Bruscia EM, VanArnam JS, Krause DS. Lack of a Fusion Requirement for Development of Bone Marrow Derived Epithelium. Science 2004 305 (5680) p90-3. *co-first author

Herzog EL, L. Chai, and DS Krause. Plasticity of Marrow Derived Stem Cells. Blood, 2003 102(10) 3483-3493.

Wagner TE, Frevert CM, Herzog EL, Schnapp LM. Expression of the Integrin Subunit alpha8beta1 in Murine Lung Development. J Histochem Cytochem 2003 51(10) p 1307-15.

Contact

Campus Address
Department of Internal Medicine
P.O. Box 208057
New Haven, CT 06520-8057

E-mail
erica.herzog@yale.edu