Bernard G. Forget, M.D.

Professor of Medicine and Genetics
Director, Hematology Training Program

Research Activities

Dr. Forget’s laboratory is involved in a research program concerned with the mechanisms of normal and abnormal gene expression in hematopoietic cells. Differential gene expression in highly enriched primitive hematopoietic stem cells is being analyzed, as well as the overall gene expression profile of various types of hematopoietic cells at different stages of differentiation, in order to elucidate transcriptional regulatory circuits during hematopoiesis. The laboratory is also studying the function and downstream targets of specific homeodomain transcription factors that may play an important role in hematopoietic stem cell biology. The study of the regulation of tissue-specific gene expression and hematopoietic stem cell-specific gene expression is relevant to the elucidation of mechanisms responsible for abnormal gene expression in genetic diseases and research directed at the purification of reconstituting hematopoietic stem cells for the purposes of cell therapy for hematopoietic disease.

Education

M.D., McGill University, 1963

B.A., University of Montreal, 1959

Residency: Massachusetts General Hospital, Boston, MA

Fellowship: Harvard Medical School

Recent Publications

• Costa, D, Lozovatsky, L., Gallagher, P., Forget, B.G. A novel splicing mutation of the α-spectrin gene in the original hereditary pyropoikilocytosis kindred. Blood 106:4367-4369, 2005.
• Kieusseian, A, Chagraoui, J., Kerdudo C, Mangeot, P., Gage, P., Navarro, N., Izac, B., Uzan, G., Forget, B.G., Dubart-Kupperschmitt, A. Expression of Pitx2 in stromal cells is required for normal hematopoiesis. Blood 107:492-500, 2006.
• Zhang, H., Degar, B., Rogoulina, S., Resor, C., Booth, C., Sinning, J., Gage, P., Forget, B.G. Hematopoiesis following disruption of the Pitx2 homeodomain gene. Exp. Hemat. 34: 167-178, 2006

Contact

Campus Address
WWW 403

E-mail
bernard.forget@yale.edu

Office Phone
(203) 785-4144

Fax
(203) 785-7232