Jack A. Elias, M.D.

Chairman, Department of Internal Medicine
Waldemar Von Zedtwitz Professor of Medicine Chief, Beeson Medical Service YNHH

Educational Background

Medical School: University of Pennsylvania School of Medicine, Philadelphia, PA

Residency: Tufts-New England Medical Center, Boston, MA, and the Hospital of the University of Pennsylvania

Fellowship: Allergy and Immunology ø Hospital of the University of Pennsylvania, Pulmonary and Critical Care Medicine ø Hospital of the University of Pennsylvania

Clinical Interests

Asthma, COPD, interstitial lung disease, acute lung injury.

Research Interests

1. Cellular and Molecular Pathogenesis of Asthma and COPD.
2. Cellular and Molceular Mechanisms of Lung Injury, Repair and Remodeling.
3. Transgenic Modeling of pulmonary diseases and disorders
4. Effector mechanisms of IL-13, VEGF, and TGF-beta type cytokines in the lung.
5. Effector mechanisms of Th2 and Th1 cytokines in the lung.

Representative Publications

• Wang, J.M., Chen, Q., Corne, J., Zhu, ZS., Lee, G.G., Bhandari, V., Homer, R.J., and Wlias, J.A. Pulmonary exression of leukemia inhibitory factor induces B cell hyperplasia and confers protection in hyperoxia. J. Biol. Chem. 278(33): 31226-32, 2003
• Blackburn, M.R., Lee, C.G., Young, H.W.J., Chunn, J.L., Banerjee, S.K. and Elias, J.A. Adenosine is an important mediator of IL-13 induced inflammation in the lung: Evidence for anIL-13-adenosine amplification pathway. J. Clin. Invest. 112: 332-334, 2003.
• Zheng, T., Zhou, Z., Liu, W., Lee, C.G., Chen, Q., Homer, R.J., and Elias, J.A. Cytokine regulation of IL-13R 2 and IL-13R 1 in vivo and in vitro. J. Allergy Clin. Immunol. 111:720-728, 2003.
• Elias, J.A., Lee, C.G., Zheng, T., Ma, B., Homer, R.J., and Zhu, Z. Science in Medicine Series, New Insights into the pathogenesis of asthma. J. Clin. Invest. 111:291-297, 2003.
• Lee, C.G., Homer, R.J., Cohn, L., Link, H., Jung, S., Craft, J.E., Graham, B.S., Johnson, T.R., and Elias, J.A. Transgenic overexpression of IL-10 in the lung causes mucusmetaplasia, tissue inflammation and airways remodeling via IL-13-dependent and independent pathways. J. Biol. Chem. 277:35466-35474, 2002.
• Zhu, Z., Ma, B., Homer, R.J., Zheng, T. and Elias, J.A. Use of the tetracycline-Controlled transcriptional silencer (tTS) to eliminate transgene leak in inducible overexpression transgenic mice. J. Biol. Chem. 276:5222-5229, 2001.
• Lee, C.G., Homer, R.J., Zhu, Z., Lanone, S., Wang, X., Koteliansky, V., Shipley, J.M., Gotwals, P., Noble, P., Senior, R.M. and Elias, J.A. Interleukin-13 induces tissue fibrosis by selectively stimulating and activating TGF-§1. J. Exp. Med. 194:809-821, 2001.
• Wang, J.M., Homer, R.J., Hong, L., Cohn, L., Lee, C.G. and Elias, J.A. IL-11 selectively inhibits aeroallergen-induced pulmonary eosinophilia and Th2 cytokine production. J. Immunol. 165:2222-2231, 2000.
• Corne, J., Chupp, G., Lee, C.G., Homer, R.J., Roux, F., McArdle, J., Waxman, A.B., and Elias, J.A. IL-13 stimulates vascular endothelial cell growth factor and protects against hyperoxic acute lung injury. J. Clin. Invest. 106:783-791, 2000.
• Lee, C.G., Yoon, H.J., Zhu, Z., Link, H., Wang, Z., Gwaltney, J.M. Jr., Landry, M. and Elias, J.A. Respiratory syncytial virus stimulation of vascular endothelial cell growth factor / vascular permeability factor (VEGF / VPF) in vivo and in vitro. Am. J. Resp. Cell Molec. Biol. 23: 662-669, 2000.
• Zheng, T., Zhu, Z., Wang, Z., Homer, R.J., Ma, B., Riese, R.J. Jr., Chapman, H.A. Jr., Shapiro, S.D. and Elias, J.A. Inducible targeting of IL-13 to the adult lung causes matrix metalloproteinase- and cathepsin-dependent emphysema. J. Clin. Invest. 106: 1081-1093, 2000.
• Wang, Z., Zheng, T., Zhu, Z., Homer, R.J., Riese, R.J., Chapman Jr., H.A., Shapiro, S.D. and Elias, J.A. Interferon gamma induction of pulmonary emphysema in the adult murine lung. J. Exp. Med. 192:1587-1600, 2000.

Contact

Campus Address
Department of Internal Medicine
P.O. Box 208056
New Haven, CT 06520-8056

E-mail
jack.elias@yale.edu

Office Phone
203-785-4119

Fax
203-785-6594