Geoffrey Lowell Chupp, M.D.

Associate Professor, Department of Internal Medicine, Section of Pulmonary and Critical Care

Director, Yale Center for Asthma and Airways Disease (YCAAD)

Director, Pulmonary and Critical Care Fellowship Program

Director, Pulmonary Function Laboratory, Yale New Haven Hospital

Education

• 1982-1986 - B.S. Biology, Tufts University, Medford, MA
• 1986-1990 - M.D., George Washington School of Medicine, Washington, DC
• 1990-1993 Internal Medicine Residency, Tufts-New England Medical Center, Boston, MA
• 1993-1997 Pulmonary and Critical Care Fellowship, Boston University Medical Center, Boston, MA

Clinical Interests

Airways diseases: Asthma, COPD, Bronchiectasis
Eosinophilic lung diseases: Allergic Bronchopulmonary Aspergillosis, Eosinophilic Pneumonias, Churg Strauss Syndrome

Cardiopulmonary Exercise Testing, Pulmonary Function Testing

Research Interests

Pathogenesis of airway diseases with a focus on asthma and asthma severity The role of chitinases in the development and severity of asthma

Publications

Bhandari V, Choo-Wing R, Lee CG, Zhu Z, Nedrelow JH, Chupp GL, Zhang X, Matthay MA, Ware LB, Homer RJ, Lee PJ, Geick A, de Fougerolles AR, Elias JA.

Hyperoxia causes angiopoietin 2-mediated acute lung injury and necrotic cell death.
Nat Med. 2006 Nov;12(11):1286-93. Epub 2006 Nov 5.
PMID: 17086189 [PubMed - indexed for MEDLINE]

Khazeni N, Homer RJ, Rubinowitz AN, Chupp GL.

Massive cavitary pulmonary rheumatoid nodules in a patient with HIV.
Eur Respir J. 2006 Oct;28(4):872-4.
PMID: 17012633 [PubMed - in process]

Lee CG, Kang HR, Homer RJ, Chupp G, Elias JA.

Transgenic modeling of transforming growth factor-beta(1): role of apoptosis in fibrosis and alveolar remodeling.
Proc Am Thorac Soc. 2006 Jul;3(5):418-23. Review.
PMID: 16799085 [PubMed - indexed for MEDLINE]

Sabina AB, Williams AL, Wall HK, Bansal S, Chupp G, Katz DL.

Yoga intervention for adults with mild-to-moderate asthma: a pilot study.
Ann Allergy Asthma Immunol. 2005 May;94(5):543-8.
PMID: 15945557 [PubMed - indexed for MEDLINE]

Cohn L, Elias JA, Chupp GL.

Asthma: mechanisms of disease persistence and progression.
Annu Rev Immunol. 2004;22:789-815. Review.
PMID: 15032597 [PubMed - indexed for MEDLINE]

Zhang X, Shan P, Sasidhar M, Chupp GL, Flavell RA, Choi AM, Lee PJ.

Reactive oxygen species and extracellular signal-regulated kinase 1/2 mitogen-activated protein kinase mediate hyperoxia-induced cell death in lung epithelium.
Am J Respir Cell Mol Biol. 2003 Mar;28(3):305-15.
PMID: 12594056 [PubMed - indexed for MEDLINE]

Homer RJ, Zheng T, Chupp G, He S, Zhu Z, Chen Q, Ma B, Hite RD, Gobran LI, Rooney SA, Elias JA.

Pulmonary type II cell hypertrophy and pulmonary lipoproteinosis are features of chronic IL-13 exposure.
Am J Physiol Lung Cell Mol Physiol. 2002 Jul;283(1):L52-9.
PMID: 12060560 [PubMed - indexed for MEDLINE]

Zhu Z, Lee CG, Zheng T, Chupp G, Wang J, Homer RJ, Noble PW, Hamid Q, Elias JA.

Airway inflammation and remodeling in asthma. Lessons from interleukin 11 and interleukin 13 transgenic mice.
Am J Respir Crit Care Med. 2001 Nov 15;164(10 Pt 2):S67-70.
PMID: 11734470 [PubMed - indexed for MEDLINE]

O'Regan AW, Nau GJ, Chupp GL, Berman JS.

Osteopontin (Eta-1) in cell-mediated immunity: teaching an old dog new tricks.
Immunol Today. 2000 Oct;21(10):475-8. Review. No abstract available.
PMID: 11071524 [PubMed - indexed for MEDLINE]

Corne J, Chupp G, Lee CG, Homer RJ, Zhu Z, Chen Q, Ma B, Du Y, Roux F, McArdle J, Waxman AB, Elias JA.

IL-13 stimulates vascular endothelial cell growth factor and protects against hyperoxic acute lung injury.
J Clin Invest. 2000 Sep;106(6):783-91.
PMID: 10995789 [PubMed - indexed for MEDLINE]

Nau GJ, Chupp GL, Emile JF, Jouanguy E, Berman JS, Casanova JL, Young RA.

Osteopontin expression correlates with clinical outcome in patients with mycobacterial infection.
Am J Pathol. 2000 Jul;157(1):37-42.
PMID: 10880373 [PubMed - indexed for MEDLINE]

Elias JA, Zhu Z, Chupp G, Homer RJ.

Airway remodeling in asthma.
J Clin Invest. 1999 Oct;104(8):1001-6. Review. No abstract available.
PMID: 10525034 [PubMed - indexed for MEDLINE]

Nau GJ, Liaw L, Chupp GL, Berman JS, Hogan BL, Young RA.

Attenuated host resistance against Mycobacterium bovis BCG infection in mice lacking osteopontin.
Infect Immun. 1999 Aug;67(8):4223-30.
PMID: 10417195 [PubMed - indexed for MEDLINE]

O'Regan AW, Chupp GL, Lowry JA, Goetschkes M, Mulligan N, Berman JS.

Osteopontin is associated with T cells in sarcoid granulomas and has T cell adhesive and cytokine-like properties in vitro.
J Immunol. 1999 Jan 15;162(2):1024-31.
PMID: 9916729 [PubMed - indexed for MEDLINE]

Chupp GL, Wright EA, Wu D, Vallen-Mashikian M, Cruikshank WW, Center DM, Kornfeld H, Berman JS.

Tissue and T cell distribution of precursor and mature IL-16.
J Immunol. 1998 Sep 15;161(6):3114-9.
PMID: 9743378 [PubMed - indexed for MEDLINE]

Nau GJ, Guilfoile P, Chupp GL, Berman JS, Kim SJ, Kornfeld H, Young RA.

A chemoattractant cytokine associated with granulomas in tuberculosis and silicosis.
Proc Natl Acad Sci U S A. 1997 Jun 10;94(12):6414-9.
PMID: 9177232 [PubMed - indexed for MEDLINE]

Keane J, Balcewicz-Sablinska MK, Remold HG, Chupp GL, Meek BB, Fenton MJ, Kornfeld H.

Infection by Mycobacterium tuberculosis promotes human alveolar macrophage apoptosis.
Infect Immun. 1997 Jan;65(1):298-304.
PMID: 8975927 [PubMed - indexed for MEDLINE]

Cruikshank W, Kornfeld H, Berman J, Chupp G, Keane J, Center D.

Biological activity of interleukin-16.
Nature. 1996 Aug 8;382(6591):501-2. No abstract available.
PMID: 8700223 [PubMed - indexed for MEDLINE]

Contact

Campus Address
Pulmonary & Critical Care Medicine
P.O. Box 208057
New Haven, CT 06520-8057

E-mail
geoffrey.chupp@yale.edu

Office Phone
203-785-3207

Fax
203-785-3826

Appointments
203-785-4198

Appointments Fax
(203) 737-5453