John Wysolmerski, M.D. Associate Professor of Medicine Section of Endocrinology Department of Internal Medicine 333 Cedar Street P.O. Box 208020 New Haven, CT 06520-8020 USA Email: john.wysolmerski@yale.edu Telephone: (203) 785-7447 Fax: (203) 737-4360

• B.S., Yale University, 1982
• M.D., Yale University, 1986
• Internship and Residency, Tufts-New England Medical Center Internal Medicine, 1989
• Endocrine Fellowship, Yale University Medical School, 1993

Dr. Wysolmerski specializes in the treatment of patients with endocrine disorders. His special interests are in disorders of calcium metabolism, osteoporosis, transplantation-related bone disease, and other metabolic bone disorders such as Pagets Disease. Dr. Wysolmerski practices as part of the Yale Bone Center, a multidisciplinary team dedicated to the treatment and research of osteoporosis and other metabolic bone disorders. He is Board Certified in both Internal Medicine and Endocrinology and Metabolism and is a member of the American College of Physicians, The Endocrine Society and The American Society for Bone and Mineral Research. He is an internationally-renowned expert on the effects of calcium-regulating hormones on development and is actively involved in the study of bone disease following renal transplantation. He has been a member of the Yale Medical School faculty since 1993.


Telephone for Appointments:
(203) 737-1932

Office Address:
300 Cedar Street; TAC S-131
Box 208020
New Haven, CT 06520-8020

Research

Dr. Wysolmerski's laboratory is interested in the mechanisms by which parathyroid hormone-related protein (PTHrP) regulates fetal development. He is currently focusing on mammary gland development in the mouse as a model of PTHrP's developmental effects. His laboratory has demonstrated that PTHrP is necessary for mammary gland formation in the mouse; in the absence of PTHrP or its receptor, embryonic mammary development fails and the mammary epithelial cells die before birth. Mechanistically, it appears that PTHrP is an important participant in the epithelial-mesenchymal interactions that initiate branching morphogenesis. Our current working hypothesis is that PTHrP serves as a critical epithelial signal that regulates mesenchymal cell fate decisions in such a way as to allow the mesenchyme to support epithelial morphogenesis. The laboratory is currently focusing on defining the changes in gene expression in embryonic mesenchymal cells in response to PTHrP in order to understand the mesenchymally-derived signals that are important for the survival and morphogenesis of the mammary epithelium.

A list of Dr. Wysolmerski's publications is available via COS.