Gerald I. Shulman, M.D., Ph.D. Professor Investigator, Howard Hughes Medical Institute Section of Endocrinology Department of Internal Medicine 333 Cedar Street P.O. Box 208020 New Haven, CT 06520-8020 USA Email: gerald.shulman@yale.edu Telephone: (203) 785-5447 Fax: (203) 737-4059

• Visiting Fellow, Yale University, Molecular Biophysics & Biochemistry, 1986
• Research Fellow, Harvard Medical School, Endocrinology & Metabolism, 1984
• Postdoctoral Fellow, Yale University, Molecular Biophysics & Biochemistry, 1984
• Residency, Duke University, Medicine, 1981
• Research Fellow, Vanderbilt University, Diabetes, 1977
• B.S., University of Michigan, 1974
• M.D., Ph.D. (physiology), Wayne State University, 1979
• Fellowship: Massachusetts General Hospital/Harvard Medical School (endocrinology/metabolism)

Dr. Shulman is Professor of Medicine and Cellular and Molecular Physiology at Yale University, where he serves as Associate Section Chief of Endocrinology. He is also an Investigator of the Howard Hughes Medical Institute. Dr. Shulman is an internationally recognized diabetes researcher, and the recipient of numerous awards, including the 1997 Outstanding Scientific Achievement (Lilly) Award from the American Diabetes Association and the 1997 Diabetes Care Research Award from Boehringer-Mannheim/Juvenile Diabetes Foundation. He is a leading authority on mechanisms of insulin resistance, the role of the liver and muscle in the pathogenesis of type 2 diabetes, and the benefits of exercise in the management of diabetes. Dr. Shulman's practice is limited to the treatment of diabetes, and other disorders of glucose metabolism, with specific interests in the management of type 2 diabetes.


Office Address:

300 Cedar Street; TAC S-269
Box 9812
New Haven, CT 06520-8012

Research

Dr. Shulman's laboratory is applying non invasive (NMR and GC-MS) techniques to examine the pathogenesis of insulin resistance that occurs in patients with type 2 diabetes and obesity.

Specific questions that are being addressed are: what is the rate limiting step for muscle glucose metabolism in patients with type 2 diabetes, the mechanism by which exercise might reverse this abnormality, and the mechanism by which increases in plasma free fatty acid concentration causes insulin resistance in human muscle (Randle Cycle).

In addition, his group is also applying these techniques to examine liver and muscle glycogen and fat metabolism during prolonged exercise and its relationship to the development of fatigue during aerobic exercise.

A list of Dr. Shulman's publications is available via COS.