Rory J. McCrimmon, MD Section of Endocrinology Department of Internal Medicine P.O. Box 208020 New Haven, CT 06520-8020 USA Email: rory.mccrimmon@yale.edu Telephone: (203) 785-4644

Research

Individuals with diabetes are prone to develop iatrogenic hypoglycemia secondary to excessive insulin replacement. Hypoglycemia is greatly feared by individuals with diabetes and remains one of the principal limitations to optimal insulin-replacement therapy. The primary research interest in my laboratory is to explore the underlying mechanisms by which the brain, and in particular specific hypothalamic nuclei, sense a falling blood glucose and trigger a neuroendocrine stress response. We are also interested in studying those factors that modulate the neuroendocrine stress response in order to try and understand why this system is impaired in diabetes. On going projects use in vivo methods such microinjection, microdialysis, and gene therapy approaches to target specific hypothalamic nuclei in animal models (rat and transgenic mice) as well as neuroimaging studies in humans subjects.

Future Research

A developing, research interest in my lab is in the central (primarily hypothalamic) regulation of peripheral metabolism, energy balance and body weight.

A list of my publications can be found at: http://myprofile.cos.com/rorymccrimmon.