Gary W. Cline, Ph.D. Associate Professor Section of Endocrinology Department of Internal Medicine 333 Cedar Street P.O. Box 208020 New Haven, CT 06520-8020 USA Email: gary.cline@yale.edu Telephone: (203) 785-5934

• B.S., University of Missouri-Columbia, Columbia, MO 1978
• Ph.D. University of Missouri-Rolla, Rolla, MO 1988

Research

Diabetes melitus has a profound impact on hepatic and peripheral glucose metabolic fluxes. My studies on the biochemical mechanisms responsible for the pathophysiology of diabetes melitus primarily employ nuclear magnetic resonance spectroscopy, mass spectroscopy, and stable isotopic techniques. Using these techniques, the flux and fate of key intermediates of carbohydrate and lipid metabolism can be determined in vitro and in vivo. These techniques are developed in cell systems and small animal models and when appropriate applied to studies of human physiology. New areas of research are the application and adaptation of these techniques to the study of pancreatic beta-cell metabolism and glucose-stimulated insulin release.

Future Research

Recent dramatic improvement in the success rate of islet transplantation in humans has prompted interest for more widespread application of this methodology. My future research will explore the development of NMR based methods for non-invasive in vitro quality assessment of tissue destined for transplantation, and in vivo monitoring of islet transplants.

A list of Dr. Cline's publications is available via COS.