Albert J. Sinusas, M.D. Professor of Medicine and Diagnostic Radiology Director, Animal Research Laboratories, Section of Cardiovascular Medicine Director, Cardiovascular Nuclear Imaging & Stress Laboratories

B.S., Rensselaer Polytechnic Institute, 1979; M.D., University of Vermont, 1983; Internship and Residency - University of Oklahoma, 1983; Cardiology Fellowship Training - University of Virginia, 1986; Joined Yale Faculty 1990.

Clinical Interests: Cardiovascular imaging, stress testing, ischemic heart disease

Research Interests: Advanced cardiovascular and molecular imaging



My research is directed at development of noninvasive imaging approaches for the assessment of myocardial viability, angiogenesis, and post-infarction remodeling. This translational research employs the 3-D modalities of SPECT, PET, echocardiography and MR imaging for assessment of regional myocardial perfusion, function and metabolism, in an animal physiology laboratory, employing large and small animal models of myocardial ischemia and infarction, and peripheral arterial disease. My laboratory is currently focused on targeted molecular imaging, developing non-invasive nuclear imaging strategies for identifying the hypoxic stimulus for angiogenesis, and targeted imaging of selected integrins previously established to modulate the angiogenic process, and evaluation of the role of matrix metalloproteinases on post-infarction remodeling. The investigation of these biological processes involves, in vitro cellular and whole heart preparations, as well as ex vivo and in vivo imaging in both small and large animal models, using dedicated high-resolution and real-time 3D ultrasound imaging, hybrid SPECT-CT and PET-CT imaging, cardiac MR imaging, and fluorescent imaging systems.






Zhu Q, Piao D, Sadeghi MM, Sinusas AJ. Simultaneous optical coherence tomography imaging and beta particle detection. Optical Letters 28:1704-1706 2003

Meoli DF, Sadeghi MM, Krassilnikova S, Bourke BN, Giordano FG, Dione DP, Su H, Edwards DS, Liu S, Harris TD, Madri JA, Zaret BL, Sinusas AJ. Non-invasive imaging of myocardial angiogenesis following experimental myocardial infarction. J Clin Invest 113:1684-1691, 2004

Hua J, Dobrucki L, Sadeghi M, Zhang J, Bourke B, Cavaliere P, Song J, Chow C, Jahanshad N, vanRoyen N, Buschmann I, Madri J, Mendizabal M, Sinusas AJ. Noninvasive imaging of angiogenesis with a 99mTc-labeled peptide targeted at alpha-v beta-3 integrin following murine hindlimb ischemia. Circ. 111:3255-60, 2005

Su H, Spinale FG, Dobrucki LW, Song J, Hua J, Sweterlitsch S, Dione DP, Cavaliere P, Chow C, Bourke BN, Hu X, Azure M, Yalamanchili P, Liu R, Cheesman EH, Robinson S, Edwards DS, Sinusas AJ. Non-nvasive Targeted Imaging of Matrix Metalloproteinase Activation in a Murine Model of Post-Infarct Remodeling. Circulation 112:3157-3167, 2005

Lindsey ML, Escobar GP, Dobrucki WL, Goshorn DK, Bouges S, Mingoia JT, McClister DM, Jr., Su H, Gannon J, MacGillivray C, Lee RT, Sinusas AJ, Spinale FG. Matrix Metalloproteinase-9 Gene Deletion Facilitates Angiogenesis Following Myocardial Infarction. Am J Physiol:Heart & Circ Phys 290:232-9 2006

Yan P, Sinusas AJ, Duncan JS. Boundary element method-based regularization for recovering of LV deformation. Med Image Anal. 2007

Gropler RJ, Glover DK, Sinusas AJ, Taegtmeyer H. (Eds), Cardiovascular Molecular Imaging,  Informa Healthcare, New York, NY ( 2007)

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Last modified:Wednesday, 09-Apr-2008 12:16:39 EDT (PL).