Laboratory
Genital mucosal DC: Herpes simplex virus
Intestinal DC: Salmonella typhimurium
Lung Influenza Infection

Publications
Lab Members
Lab Album 1 Lab Album 2



Selected Publications

Iwasaki, A. (2007) Role of Autophagy in Innate Viral Recognition. Autophagy 3:4, 354-356.

Iwasaki, A. (2007) Mucosal dendritic cells. Annual Review of Immunology 25:381-418.

Iwasaki, A. (2007) Division of labor by dendritic cells. Cell 128:435-436.

Lee HK, Lund JM, Ramanathan B, Mizushima N, Iwasaki A. (2007) 315:1398-401. Science.

Lund, J. M., Linehan, M.M., Iijima N. and Iwasaki, A. (2006) Cutting Edge: Plasmacytoid dendritic cells provide innate immune protection against mucosal viral infection in situ. Journal of Immunology 177:7510-7514.

Sato, A., Linehan, M. M., and Iwasaki, A. (2006) Dual Recognition of Herpes Simplex Viruses by TLR2 and TLR9 in Dendritic Cells. Proc. Natl. Acad. Sci. 103 (46): 17343-17348.

Shen, H and Iwasaki, A. (2006) A crucial role for plasmacytoid dendritic cells in antiviral protection by CpG ODN-based vaginal microbicide. Journal of Clinical Investigation 116 (8): 2237-2243.

Iwasaki A., The use of bone marrow-chimeric mice in elucidating immune mechanisms. Methods Mol Med. (2006); 127-281-92.

Colonna, M., Pulendran, B., and Iwasaki, A. (2006) Dendritic cells at the host-pathogen interface. Nature Immunology, 7: 117-120.

Soderberg, K.A., Payne, G.W., Sato, A., Medzhitov, R., Segal, S.S., and Iwasaki, A. (2005) Innate control of adaptive immunity via remodeling of lymph node feed arteriole. Proc. Natl. Acad. Sci., 102:16315-16320.

Sato, A. and Iwasaki, A. (2005) Book Chapter in Methods in Molecular Medicine, Title: Isolation and characterization of Peyer’s patch dendritic cells.

Lund, J. Sato, A., Akira, S., Medzhitov, R. and Iwasaki, A. (2003) Toll-like receptor 9-mediated recognition of herpes simplex virus-2 by plasmacytoid dendritic cells. Journal of Experimental Medicine 198: 513-520.

Zhao, X., Sato, A., Dela Cruz, C.S., Linehan, M., Luegering, A., Kucharzik, K., Shirakawa, A-K, Marquez, G., Farber, J. M., Williams, I. and Iwasaki, A. (2003) CCL9 is secreted by the follicle associated epithelium and recruits dome region Peyer’s patch CD11b+ dendritic cells. Journal of Immunology 171:2797-2803.

Sato, A, Hashiguchi, M., Toda, E., Iwasaki, A., Hachimura, S., and Kaminogawa S. (2003) CD11b+ Peyer's patch dendritic cells secrete IL-6 and induce IgA secretion from naïve B cells. Journal of Immunology 171:3684-3690.

Iwasaki, A. Immune responses against vaginal infection by the herpessimplex virus type 2 (2003) Microbes and Infection, 5:1221-1230.

Iwasaki, A. (2003) Commentary: The importance of CD11b+ DCs in CD4+ T cell activation in vivo: with help from interleukin-1. Journal of Experimental Medicine 198:185-190.

X. Zhao, E. Deak, K. Soderberg, M. Linehan, D. Spezzano, J. Zhu, D.M. Knipe, and A. Iwasaki
(2003) Vaginal submucosal dendritic cells, but not Langerhans' cells, induce protective T helper type 1 responses to herpes simplex virus-2. J. Exp. Med. 197:153-162
.

Iwasaki, A., Welker, R., Müller, S., Nomoto, A. and Wimmer, E. (2002) Immunofluorescence Analysis of Poliovirus Receptor Expression in the Peyer's Patches of Humans, Primates and CD155 Transgenic Mice. J. Infect. Dis.186:585-592.

Jameson, B. Baribaud, F., Pöhlmann, S., Ghavimi, D., Mortari, F., Doms, R.W., and Iwasaki, A. (2002) Expression of DC-SIGN by intestinal and genital mucosal dendritic cells in humans and rhesus macaques. J. Virol. 76:1866-1875.

Iwasaki, A. and Kelsall, B.L. Unique functions of CD11b(+), CD8alpha(+), and double-negative peyer's patch dendritic cells. (2001) J. Immunol. 166:4884-4890.

Iwasaki, A. and Kelsall, B.L. Localization of distinct Peyer's patch dendritic cell subsets and their recruitment by chemokines MIP-3a and MIP-3b/SLC. (2000) J. Exp. Med. 191:1381-1393.

Iwasaki, A. and Kelsall, B.L. Freshly isolated Peyer's patch, but not spleen dendritic cells produce IL-10 and induce the differentiation of Th2 cells. (1999) J. Exp. Med. 190:229-240.

Iwasaki, A. and Kelsall, B.L. Mucosal immunity and inflammation I. Mucosal dendritic cells: their specialized role in initiating T cell responses. (1999) American J. Physiol. 276 : Gastrointestinal Liver Physiology 39: G1074-G1078.

Iwasaki, A., C.A.T. Torres, P.S. Ohashi, H.L. Robinson, and B.H. Barber. Both gene gun and intramuscular injection of plasmid DNA induce cytotoxic T-lymphocytes via bone marrow derived antigen presenting cells. (1997) J. Immunol. 159:11-1

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  Last modified: October 22, 2007.

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