Toll Like Receptors & TLR Signaling to NF-kB
TLRs mediate crucial events in both the adaptive and innate immune responses. In their capacity as mediators of pathogen recognition they initiate signaling pathways, including the activation of NF-kB, that are required for innate antimicrobial functions and initiation of the adqaptive immune response. Work in our lab has focused on the dissection of signaling events downstream of TLRs, as well as the characterization of novel mammalian Toll-like receptors.
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Shim, J.H., et al. TAK1, but not TAB1 or TAB2, plays an essential role in multiple signaling pathways in vivo. Genes Dev. 2005
Yarovinsky F et al. TLR11 activation of dendritic cells by a protozoan profilin-like protein. Science. 2005.
Zhang D et al. A toll-like receptor that prevents infection by uropathogenic bacteria. Science, 2004
Zhang G & Ghosh S. Toll-like receptor-mediated NF-kappaB activation: a phylogenetically conserved paradigm in innate immunity. JCI, 2001
Zhang G & Ghosh S. Molecular mechanisms of NF-kappaB activation induced by bacterial lipopolysaccharide through Toll-like receptors. Journal of Endotoxin Research, 2000.
Zhang G & Ghosh S. Molecular mechanisms of NF-kappaB activation induced by bacterial lipopolysaccharide through Toll-like receptors. Journal of Endotoxin Research, 2000.
Kopp E et al. ECSIT is an evolutionarily conserved intermediate in the Toll/IL-1 signal transduction pathway. Genes & Development 1999
Ghosh Lab