Publications

Selected Publications

• Yang J, Boerm M, McCarty M, Bucana C, Fidler J, Zhuang Y, and Su B. Essential role of MEKK3 in early embryonic cardiovascular development. Nature Genetics 24:309-313, 2000.
• Yang J., Lin Y., Guo Z, Cheng J, Huang H, Liao W, Chen Z, Liu Z,and Su B. The essential role of MEKK3 in TNF-induced NF-kB activation. Nature Immunology 2:620-624, 2001.
• Zijian Guo, Gavin Clydesdale, Jinke Cheng, David J. McConkey, Stephen E. Ullrich, Yuan Zhuang, and Su B. MEKK2 Negatively Regulates T-cell Receptor Signal Transduction. Mol. Cell. Biol. 22:5761-5768, 2002.
• Thomas H. Lee, Qiaojia Huang, Sarah Oikemus, Jennifer Shank, Juan-Jose Ventura, Nicole Cusson, Richard R. Vaillancourt, Su B, Roger J. Davis and Michelle A. Kelliher. The death domain kinase RIP 1 is essential for TNF-a signaling to p38 MAP kinase. Mol. Cell. Biol. 2003.
• Qiaojia Hunag, Jianhua Yang, Jinke Cheng, CM Walker, Z.G. Liu, and Su B. Differential regulation of interleukin-1 receptor and toll like receptor (TLR) signaling by MEKK3. Nature Immunology, 5:95-103, 2004.
• Jinke Cheng, Ling Yu, Dongyu Zhang, Qiaojia Huang, David Spencer, and Su B.  Dimerization through the catalytic domain is essential for MEKK2 activation.  J. Biol. Chem. 280:13477-82, 2005.
• Su B.  Linking stress to immunity? Nat Immunol. 6:541-542, 2005.
• Jinke Cheng, Dongyu Zhang, Kihwan Kim, Yingxin Zhao, Yingming Zhao, and Su B.  Mip1, an MEKK2 Interacting Protein, Regulates MEKK2 Dimerization and Activation.  Mol. Cell. Biol. 25(14):5955-5964, 2005.
• Dongyu Zhang, Valeria Fachinnetti, Xiaofang Wang, Qiaojia Huang, Jun Qin and Su B. Identification of MEKK2/3 serine phosphorylation site targeted by the Toll-like receptor- and stress-pathways.  EMBO J. 25, 97-107, 2006.
• Deng M, Chen WL, Takatori A, Peng Z, Zhang L, Mongan M, Parthasarathy R, Sartor M, Miller M, Yang J, Su B., Kao WW, Xia Y. A role for the mitogen-activated protein kinase kinase kinase 1 in epithelial wound healing. Mol Biol Cell. 2006; 17(8):3446-55.
• Jacinto E, Facchinetti V, Liu D, Soto N, Wei S, Jung SY, Huang Q, Qin J, Su B. SIN1/MIP1 maintains rictor-mTOR complex integrity and regulates Akt phosphorylation and substrate specificity. Cell. 2006;127(1):125-37.
• Kihwan Kim, Omar Duramad, Xiaofeng Qin and Su B. MEKK3 Is Essential for Lipopolysaccharide-induced IL-6 and GM-CSF Production in Macrophages.  In press, Immunology, 2006.