Publications

Publications (2002-2007) and Citations from Research Interests (various years)

• Anderson, B. E., McNiff, J., Yan, J., Doyle, H., Mamula, M., Shlomchik, M. J., and Shlomchik, W. D. (2003). Memory CD4+ T cells do not induce graft-versus-host disease. J Clin Invest 112, 101-108.
• Anderson, B. E., McNiff, J. M., Jain, D., Blazar, B. R., Shlomchik, W. D., and Shlomchik, M. J. (2005). Distinct roles for donor- and host-derived antigen-presenting cells and costimulatory molecules in murine chronic graft-versus-host disease: requirements depend on target organ. Blood 105, 2227-2234.
• Anderson, B. E., McNiff, J. M., Matte, C., Athanasiadis, I., Shlomchik, W. D., and Shlomchik, M. J. (2004). Recipient CD4+ T cells that survive irradiation regulate chronic graft-versus-host disease. Blood 104, 1565-1573.
• Anderson, S. E., Tomayko, M. M., and Shlomchik, M. J. (2006a). Intrinsic Properties of Human and Murine Memory B Cells. Immunological Rev 211, 280-294.
• Anderson, S. M., Hannum, L. G., and Shlomchik, M. J. (2006b). Memory B cell survival and function in the absence of secreted antibody and immune complexes on follicular dendritic cells. J Immunol 176, 4515-4519.
• Bach, J. F., Bendelac, A., Brenner, M. B., Cantor, H., De Libero, G., Kronenberg, M., Lanier, L. L., Raulet, D. H., Shlomchik, M. J., and von Herrath, M. G. (2004). The role of innate immunity in autoimmunity. J Exp Med 200, 1527-1531.
• Beaudette-Zlatanove, B. C., LIng, T., Shlomchik, M. J., Marshak-Rothstein, A., and Rifkin, I. R. (2006). B cells and dendritic cells from Vk8 light chain transgenic mice activate MRL-lpr/gld CD4+ T cells. J  Immunol in press.
• Chan, O., and Shlomchik, M. J. (1998). A new role for B cells in systemic autoimmunity: B cells promote spontaneous T cell activation in MRL-lpr/lpr mice. J Immunol 160, 51-59.
• Chan, O. T., Hannum, L. G., Haberman, A. M., Madaio, M. P., and Shlomchik, M. J. (1999). A novel mouse with B cells but lacking serum antibody reveals an antibody-independent role for B cells in murine lupus. J Exp Med 189, 1639-1648.
• Christensen, S. R., Kashgarian, M., Alexopoulou, L., Flavell, R. A., Akira, S., and Shlomchik, M. J. (2005). Toll-like receptor 9 controls anti-DNA autoantibody production in murine lupus. J Exp Med 202, 321-331.
• Christensen, S. R., Shupe, J., Nickerson, K., Kashgarian, M., Flavell, R. A., and Shlomchik, M. J. (2006). Toll-like receptor 7 and TLR9 dictate autoantibody specificity and have opposing inflammatory and regulatory roles in a murine model of lupus. Immunity 25, 417-428.
• Dal Porto, J. M., Haberman, A. M., Kelsoe, G., and Shlomchik, M. J. (2002). Very low affinity B cells form germinal centers, become memory B cells, and participate in secondary immune responses when higher affinity competition is reduced. J Exp Med 195, 1215-1221.
• Haberman, A. M., and Shlomchik, M. J. (2003). Reassessing the function of immune-complex retention by follicular dendritic cells. Nat Rev Immunol 3, 757-764.
• Haberman, A. M., William, J., Euler, C., and Shlomchik, M. J. (2003). Rheumatoid factors in health and disease: structure, function, induction and regulation. Curr Dir Autoimmun 6, 169-195.
• Hannum, L. G., Haberman, A. M., Anderson, S. M., and Shlomchik, M. J. (2000). Germinal center initiation, variable gene region hypermutation, and mutant B cell selection without detectable immune complexes on follicular dendritic cells. J Exp Med 192, 931-942.
• Hannum, L. G., Ni, D., Haberman, A. M., Weigert, M. G., and Shlomchik, M. J. (1996). A disease-related RF autoantibody is not tolerized in a normal mouse: implications for the origins of autoantibodies in autoimmune disease. J Exp Med 184, 1269-1278.
• Kaplan, D. H., Anderson, B. E., McNiff, J. M., Jain, D., Shlomchik, M. J., and Shlomchik, W. D. (2004). Target antigens determine graft-versus-host disease phenotype. J Immunol 173, 5467-5475.
• Kaplan, D. H., Jenison, M. C., Saeland, S., Shlomchik, W. D., and Shlomchik, M. J. (2005). Epidermal langerhans cell-deficient mice develop enhanced contact hypersensitivity. Immunity 23, 611-620.
• Kleinstein, S. H., Louzoun, Y., and Shlomchik, M. J. (2003). Estimating hypermutation rates from clonal tree data. J Immunol 171, 4639-4649.
• Lau, C. M., Broughton, C., Tabor, A. S., Akira, S., Flavell, R. A., Mamula, M. J., Christensen, S. R., Shlomchik, M. J., Viglianti, G. A., Rifkin, I. R., and Marshak-Rothstein, A. (2005). RNA-associated autoantigens activate B cells by combined B cell antigen receptor/Toll-like receptor 7 engagement. J Exp Med 202, 1171-1177.
• Leadbetter, E. A., Rifkin, I. R., Hohlbaum, A. M., Beaudette, B. C., Shlomchik, M. J., and Marshak-Rothstein, A. (2002). Chromatin-IgG complexes activate B cells by dual engagement of IgM and Toll-like receptors. Nature 416, 603-607.
• Novobrantseva, T. I., Majeau, G. R., Amatucci, A., Kogan, S., Brenner, I., Casola, S., Shlomchik, M. J., Koteliansky, V., Hochman, P. S., and Ibraghimov, A. R. (2005). Attenuated liver fibrosis in the absence of B cells. J Clin Invest 115, 3072-3082.
• O'Neill S, K., Shlomchik, M. J., Glant, T. T., Cao, Y., Doodes, P. D., and Finnegan, A. (2005). Antigen-specific B cells are required as APCs and autoantibody-producing cells for induction of severe autoimmune arthritis. J Immunol 174, 3781-3788.
• Odegard, V. H., Kim, S. T., Anderson, S. M., Shlomchik, M. J., and Schatz, D. G. (2005). Histone modifications associated with somatic hypermutation. Immunity 23, 101-110.
• Ramakrishna, C., Stohlman, S. A., Atkinson, R. D., Shlomchik, M. J., and Bergmann, C. C. (2002). Mechanisms of central nervous system viral persistence: the critical role of antibody and B cells. J Immunol 168, 1204-1211.
• Rossbacher, J., Haberman, A. M., Neschen, S., Khalil, A., and Shlomchik, M. J. (2006). Antibody-independent B cell intrinsic and extrinsic roles for CD21/35. Eur J Immunol in press.
• Rossbacher, J., and Shlomchik, M. J. (2003). The B cell receptor itself can activate complement to provide the complement receptor 1/2 ligand required to enhance B cell immune responses in vivo. J Exp Med 198, 591-602.
• Shlomchik, M. J., Cooke, A., and Weigert, M. (2004). Autoimmunity: The genes and phenotypes of autoimmunity. Curr Opin Immunol 16, 738-740.
• Shlomchik, M. J., Euler, C. W., Christensen, S. C., and William, J. (2003). Activation of rheumatoid factor (RF) B cells and somatic hypermutation outside of germinal centers in autoimmune-prone MRL/lpr mice. Ann N Y Acad Sci 987, 38-50.
• Shlomchik, M. J., and Madaio, M. P. (2003). The role of antibodies and B cells in the pathogenesis of lupus nephritis. Springer Semin Immunopathol 24, 363-375.
• Shlomchik, M. J., Madaio, M. P., Ni, D., Trounstine, M., and Huszar, D. (1994). The role of B cells in lpr/lpr-induced autoimmunity. J Exp Med 180, 1295-1306.
• Shlomchik, W. D., Cormier, J., Matte, C., Anderson, B. E., and Shlomchik, M. J. (2002). Costimulation, Activation and Maturation of Host APCs during GVHD. Blood 100, 820.
• Viglianti, G. A., Lau, C. M., Hanley, T. M., Miko, B. A., Shlomchik, M. J., and Marshak-Rothstein, A. (2003). Activation of autoreactive B cells by CpG dsDNA. Immunity 19, 837-847.
• Wang, H., and Shlomchik, M. J. (1999). Autoantigen-specific B cell activation in Fas-deficient rheumatoid factor immunoglobulin transgenic mice. J Exp Med 190, 639-649.
• William, J., Euler, C., Christensen, S., and Shlomchik, M. J. (2002). Evolution of autoantibody responses via somatic hypermutation outside of germinal centers. Science 297, 2066-2070.
• William, J., Euler, C., Leadbetter, E., Marshak-Rothstein, A., and Shlomchik, M. J. (2005a). Visualizing the onset and evolution of an autoantibody response in systemic autoimmunity. J Immunol 174, 6872-6878.
• William, J., Euler, C., Primarolo, N., and Shlomchik, M. J. (2006). B cell tolerance checkpoints that restrict pathways of antigen-driven differentiation. J Immunol 176, 2142-2151.
• William, J., Euler, C., and Shlomchik, M. J. (2005b). Short-lived plasmablasts dominate the early spontaneous rheumatoid factor response: differentiation pathways, hypermutating cell types, and affinity maturation outside the germinal center. J Immunol 174, 6879-6887.
• Wong, F. S., Wen, L., Tang, M., Ramanathan, M., Visintin, I., Daugherty, J., Hannum, L. G., Janeway, C. A., Jr., and Shlomchik, M. J. (2004). Investigation of the role of B-cells in type 1 diabetes in the NOD mouse. Diabetes 53, 2581-2587.