Research Interests

Selected publications from the last five years

• Liu, M., Duke, J.L., Richter, D.J., Vinuesa, C.G., Goodnow, C.C., Kleinstein, S.H., and Schatz, D.G. (2008). Two levels of protection for the B cell genome during somatic hypermutation. Nature 451, 841-845.
• Unniraman, S., and Schatz, D.G. (2007). Strand-biased spreading of mutations during somatic hypermutation. Science 317, 1227-1230.
• Yang, S.Y., Fugmann, S.D., Gramlich, H.S., and Schatz, D.G. (2007). Activation-induced cytidine deaminase-mediated sequence diversification Is transiently targeted to newly integrated DNA substrates. J Biol Chem 282, 25308-25313.
• Ciubotaru, M., Kriatchko, A.N., Swanson, P.C., Bright, F.V., and Schatz, D.G. (2007). Fluorescence resonance energy transfer analysis of recombination signal sequence configuration in the RAG1/2 synaptic complex. Mol Cell Biol 27, 4745-4758.
• Drejer-Teel, A.H., Fugmann, S.D., and Schatz, D.G. (2007). The beyond 12/23 restriction is imposed at the nicking and pairing steps of DNA cleavage during V(D)J recombination. Mol Cell Biol 27, 6288-6299.
• Chatterji, M., Tsai, C.L., and Schatz, D.G. (2006). Mobilization of RAG-generated signal ends by transposition and insertion in vivo. Mol Cell Biol 26, 1558-1568.
• Yang, S.Y., Fugmann, S.D., and Schatz, D.G. (2006). Control of gene conversion and somatic hypermutation by immunoglobulin promoter and enhancer sequences. J Exp Med 203, 2919-2928.
• Odegard, V.H., Kim, S.T., Anderson, S.M., Shlomchik, M.J., and Schatz, D.G. (2005). Histone modifications associated with somatic hypermutation. Immunity 23, 101-110.
• Rush, J.S., Liu, M., Odegard, V.H., Unniraman, S., and Schatz, D.G. (2005). Expression of activation-induced cytidine deaminase is regulated by cell division, providing a mechanistic basis for division-linked class switch recombination. Proc Natl Acad Sci USA 102, 13242-13247.
• Ciubotaru, M., and Schatz, D.G. (2004). Synapsis of recombination signal sequences located in cis and DNA underwinding in V(D)J recombination. Mol Cell Biol 24, 8727-8744.
• Unniraman, S., Zhou, S., and Schatz, D.G. (2004). Identification of an AID-independent pathway for chromosomal translocations between the Igh switch region and Myc. Nat Immunol 5, 1117-1123.