Publications

Selected Publications

• Iijima N, Linehan MM, Saeland S and Iwasaki, A. Vaginal epithelial dedritic cells renew from bone marrow precursors. Proc. Natl Nacd. Sci. 104: 19061-19066, 2007
• Thompson JM, Iwasaki A. Toll-like receptors regulation of viral infection and disease. Adv Drug Deliv Rev. in press, 2008.
• Lee HK, Iwasaki A. Autophagy and antiviral immunity. Curr Opin Immunol. in press, 2008.
  
• Lee HK and Iwasaki A. Innate control of adaptive imunity: dendritic cells and beyond.  Semin Immunol. 19(1):48-55, 2007.
• Iwasaki A. Division of labor by dendritic cells. Cell 128(3):435.6, 2007.
• Iwasaki A.  Mucosal dendritic cells. Annual Review of Immunology 25:381-418, 2007.
• Iwasaki A. Role of autophagy in innate viral recognition.  Autophagy 3(4):354-6, 2007.Lee HK, Lund JM, Ramanathan B, Mizushima N, Iwasaki A. (2007) Autophagy-Dependent Viral Recognition by Plasmacytoid Dendritic Cell. Science. 2007 Feb 1; [Epub ahead of print]
• Lund JM, Linehan MM, Iijima N, Iwasaki A. (2006) Cutting Edge: Plasmacytoid dendritic cells provide innate immune protection against mucosal viral infection in situ. J Immunol. 177(11):7510-4.
• Sato A, Linehan MM, Iwasaki A. (2006) Dual recognition of herpes simplex viruses by TLR2 and TLR9 in dendritic cells. Proc Natl Acad Sci U S A. 103(46):17343-8.
• Shen H, Iwasaki A. (2006) A crucial role for plasmacytoid dendritic cells in antiviral protection by CpG ODN-based vaginal microbicide. J Clin Invest. 116(8):2237-43.
• Colonna, M., Pulendran, B., and Iwasaki, A. (2006) Dendritic cells at the host-pathogen interface. Nat Immun 7: 117-120.
• Soderberg, K.A., Payne, G.W., Sato, A., Medzhitov, R., Segal, S.S., and Iwasaki, A. (2005) Innate control of adaptive immunity via remodeling of lymph node feed arteriole. Proc. Natl. Acad. Sci. 102:16315-16320.
• Sato, A. and Iwasaki, A. (2005) Peyer's patch dendritic cells as regulators of mucosal adaptive immunity. Cell. Mol. Life Sci. 62:1333-1338.
• Sato, A. and Iwasaki, A. (2004) Induction of antiviral immunity requires Toll-like receptor signaling in both stromal and dendritic cell compartments. Proc. Natl. Acad. Sci. 101:16274-16279. Commentary.
• Iwasaki, A. and Medzhitov, R. (2004) Toll-like receptor control of the adaptive immune responses. Nat Immunol. 5: 987-995.
• Lund, J.M., Alexopoulou, L., Sato, A., Karow, M., Adams, N.C., Gale, N.W., Iwasaki, A, and Flavell, R.A. (2004) Recognition of single-stranded RNA viruses by Toll like receptor 7. Proc. Natl. Acad. Sci. 101:5598-5603. Commentary
• Linehan, M.M., Richman, S., Krummenacher, C., Eisenberg, R., Cohen, G., and Iwasaki, A. (2004) In vivo role of Entry of herpes simplex virus type 1 (HSV-1) and HSV-2 through vaginal mucosa. J Virol. 78:2530-2536.
• Soderberg KA, Linehan MM, Ruddle NH, Iwasaki A. (2004) MAdCAM-1 Expressing Sacral Lymph Node in the Lymphotoxinb-Deficient Mouse Provides a Site for Immune Generation Following Vaginal Herpes Simplex Virus-2 Infection1. J Immunol 173:1908-1913.
• Iwasaki, A. Invited Review: The role of dendritic cells in immune responses against vaginal infection by the herpes simplex virus type 2 (2003) Microb Infect. 5:1221-1230.
• Lund, J. Sato, A., Akira, S., Medzhitov, R. and Iwasaki, A. (2003) Toll-like receptor 9-mediated recognition of herpes simplex virus-2 by plasmacytoid dendritic cells. J Exp Med 198: 513-520.
• Zhao, X., Sato, A., Dela Cruz, C.S., Linehan, M., Luegering, A., Kucharzik, K., Shirakawa, A-K, Marquez, G., Farber, J. M., Williams, I. and Iwasaki, A. (2003) CCL9 is secreted by the follicle associated epithelium and recruits dome region Peyer's patch CD11b+ dendritic cells. J Immunol 171:2797-2803.
• Iwasaki, A. Immune responses against vaginal infection by the herpessimplex virus type 2 (2003) Microb Infect 5:1221-1230.
• Iwasaki, A. (2003) Commentary: The importance of CD11b+ DCs in CD4+ T cell activation in vivo: with help from interleukin-1. J Exp Med 198:185-190.
• X. Zhao, E. Deak, K. Soderberg, M. Linehan, D. Spezzano, J. Zhu, D.M. Knipe, and A. Iwasaki(2003) Vaginal submucosal dendritic cells, but not Langerhans' cells, induce protective T helper type 1 responses to herpes simplex virus-2. J Exp Med. 197:153-162.
• Iwasaki, A., Welker, R., Müller, S., Nomoto, A. and Wimmer, E. (2002) Immunofluorescence Analysis of Poliovirus Receptor Expression in the Peyer's Patches of Humans, Primates and CD155 Transgenic Mice. J. Infect. Dis 186:585-592.
• Jameson, B. Baribaud, F., Pöhlmann, S., Ghavimi,D., Mortari, F., Doms, R.W., and Iwasaki, A. (2002) Expression of DC-SIGN by intestinal and genital mucosal dendritic cells in humans and rhesus macaques. J. Virol. 76:1866-1875.