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Grant Abstract
The tenet of this proposal is that progress in
biomedical research is increasingly dependent upon high throughput
biotechnological advances (e.g., automated DNA sequencing, DNA microarray
analysis of mRNA expression, mass spectrometric-based proteome profiling, and
several emerging technologies for SNP genotyping) that are increasingly limited
by the inability of the "personal computers" and small departmental clusters
available to Yale investigators to adequately and timely analyze the enormous
volume of the resulting data. While recent biotechnological breakthroughs have
brought us to the exciting threshold of systems level biomedical research, to
take advantage of these technologies Yale investigators will need far more
powerful computers than are now within their reach and a commensurate level of
technical programming and systems administration support. The proposed Center
for High Performance Computation in Biomedicine at Yale would utilize the
requested instrumentation and would serve as a focal point for the staff and
physical infrastructure needed to bring computer science to bear on challenging,
yet amenable problems that stand in the way of biomedical research.
The strengths of this proposal include the very diverse and productive
investigator user base that would support the proposed Center, the demonstrated
ability over the last 24 years of the PI and the Keck Laboratory he oversees to
continually operate and maintain sophisticated biotechnological instrumentation
and to bring it within reach of hundreds of Yale and non-Yale researchers, the
extensive infrastructure and expertise that is available to bring the requested
instrumentation on-line and to oversee and support its continuous use, and the
careful planning and very firm support of both Yale University and its School of
Medicine to ensure that this proposal represents a coordinated and well
conceived institutional response to the challenge of providing the high
performance computing needed to drive biomedical research forward.
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