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Kevin White |
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| Visiting Professor |
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Associate Professor of Genetics
* B.S./M.S. Yale College, 1993
* Ph.D. Stanford University, 1998
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| Research Interests: | |
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| Genomics and bioinformatics, transcriptional regulatory networks, nuclear
receptor function and specificity, transcriptional variation within and
between species, comparative genomics.
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| Honors: | |
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Arnold and Mabel Beckman Young Investigator 2004
W.M. Keck Young Investigator in Medical Sciences 2003
NIH Genome Scholar 2000
Helen Hay Whitney Fellow 1998
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| Current Research: | |
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The White lab studies the coordinated action of networks of genes that control developmental
processes. To build models of the transcriptional networks that control development, we are
taking an integrated approach that makes use of gene expression microarrays, large-scale
protein-protein and protein-DNA interaction analyses, systematic RNAi analysis and high
throughput polymorphism detection. By applying our methods to both closely and distantly
related species, we are investigating how conserved molecular networks control basic developmental
processes and how variation in molecular networks translates into variation in organismal phenotypes. We
are particularly interested in the transcriptional networks controlled by nuclear receptor proteins. We
also are studying the transcriptional mechanisms involved in patterning the early embryo. We make
use of the compact Drosophila genome and the genomes of related species as model systems for many
of our studies. We have also begun to apply these genomics and computational approaches to
investigations of the human genome.
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The image below is a Drosophila DNA microarray hybridized using RNA transcripts prepared before (green) and after (red) the onset of metamorphosis. The
extreme changes in gene expression during this time in development reflect the complex morphological restructuring of the animal that is taking place.
Studying gene expression changes during development on a genome-wide scale is one strategy that we use to relate complex phenotypic traits to the genetic
networks that underlie them.
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| Representative Publications: | |
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S.A. Rifkin, D. Houle, J. Kim and K.P. White. "A mutation accumulation
assay reveals extensive capacity for rapid gene expression evolution"
Nature, in press (2005).
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| V. Stolc, Z. Gauhar, C. Mason et al. A Gene Expression Map for the Euchromatic Genome of Drosophila melanogaster. Science, in Science, (2004) 306(5696):655-60.
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| L. Giot et al. A protein interaction map of Drosophila melanogaster. Science. 2003 302(5651):1727-36.
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| S.A. Rifkin, J. Kim, K.P. White. Evolution of gene expression in the Drosophila melanogaster subgroup. Nature Genetics. 2003 33(2)138-44.
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T.R. Li and K.P. White. Tissue-specific gene expression and ecdysone-regulated genomic networks in Drosophila. Dev. Cell. 2003 5(1):59-72.
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M.N. Arbeitman et al. Gene expression during the life cycle of Drosophila melanogaster. Science. 2002 297(5590)2270-75.
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| Contact Information: | |
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