|
|
|
|
Kei-Hoi Cheung |
|
|
| Assistant Professor, Yale Center for Medical Informatics |
 |  |  |
|
* B.S. Southern Connecticut State University, 1989
* Ph.D. University of Connecticut, 1998
|
| | |
 | |  |
|
| Research Interests: | |
| | |
|
| Genetic database and tool interoperation
As an increasing number of databases and tools are presently accessible to the life sciences research community over the Internet, we have realized the importance of database and tool interoperation in facilitating genome-wide research. In addition to the large data quantity, the growing number, heterogeneity, and variety of the available databases and tools have posed a major interoperability challenge. We tackle this challenge by exploring efficient and innovative data and tool interoperation approaches involving the use of XML, semantic web, metadata, distributed computing, and high performance computing. We have been collaborating with many faculty members in different departments and core facilities including Genetics, Biology, Computer Science, Biostatistics, Yale Keck Microarray Facility, and Yale Keck Protein Profiling Facility. Our research is carried out in the context of integrating and analyzing: a) microarray data, b) proteomics data including mass spectrometry (MS) data, c) single nucleotide polymorphism (SNP) data, and d) yeast genome data. Related projects include: a) Yale Microarray Database (YMD), b) Yale Protein Expression Database (YPED), c) Allele Frequency Database (ALFRED), and d) YeastHub.
|
| | |
| | |
|
| Ongoing projects: | | |
|
| YCMI lectures (2002): | | |
|
| Biomedical Informatics Course, Spring 2003 (Bioinformatics Database/Tool Interoperability): | | |
|
| Representative Publications: | |
| | |
|
| Pedrioli PG, Eng JK, Hubley R, Vogelzang M, Deutsch EW, Raught B, Pratt B, Nilsson E, Angeletti RH, Apweiler R, Cheung K, Costello CE, Hermjakob H, Huang S, Julian RK, Kapp E, McComb ME, Oliver SG, Omenn G, Paton NW, Simpson R, Smith R, Taylor CF, Zhu W, Aebersold R. (2004). A common open representation of mass spectrometry data and its application to proteomics research. Nature Biotechnology 22(11):1459-66.
|
| | |
| | |
|
| |
| | |
|
|
Cheung KH, deKnikker R, Guo Y, Zhong G, Hager J, Yip KY, Kwan AKH, Li P, Cheung DW. (2004). Biosphere: the interoperation of web services in microarray cluster analysis. Applied Bioinformatics 3(4):253-6.
|
| | |
| | |
|
| |
| | |
|
| Cheung KH, et. al. (2005) YeastHub: a semantic web use case for integrating data in the life sciences domain. Bioinformatics 21(Suppl. 1): i85-i96.
|
| | |
| | |
|
| Contact Information: | | |
|
|
