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Joel Gelenter, MD |
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| Professor of Psychiatry Director, Division of Human Genetics in Psychiatry |
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* NIH Medical Staff Fellowship
* NIMH Level I Career Award; NIMH Independent Scientist Career Award
* Member, American College of Neuropsychopharmacology
Associate editor, Neuropsychopharmacology (2006 -)
Editorial board member, Psychiatric Genetics (1994 - )
Editorial board member, Biological Psychiatry (1997 - )
Editorial board member, Asian Biomedicine (Research, Reviews and News) (2006 - )
Editorial board member, American Journal of Medical Genetics, Part B (2007 - )
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| Research Interests: | |
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| The research focus of my laboratory is genetics of psychiatric illness. We study a
range of behavioral phenotypes including cocaine, opiate, nicotine, and ethanol
dependence, panic and other anxiety disorders, schizophrenia, and affective disorders.
In addition we study a range of intermediate phenotypes, such as neuroimaging measures;
and basic issues in population genetics. The overall approach involves study of genetic
polymorphism, both on a molecular level, and from the perspective of population genetics.
Current studies include two large NIH (NIDA)-funded multicenter affected sibling
pair genomewide linkage studies with the goal of identifying genes predisposing to
cocaine, opioid, and tobacco dependence; a multicenter NIAAA-funded study in mapping
by admixture linkage disequilibrium (MALD) for alcohol dependence; a study using small
nuclear families to identify genomic regions in linkage disequilibrium with alcohol
dependence; and a full genome scan (using linkage) with the goal of identifying loci
predisposing to panic disorder, agoraphobia, social phobia, and simple phobia. Additional
projects include mutation detection studies for candidate genes, studies of within-locus
linkage disequilibrium at candidate loci, fine-mapping a locus for simple phobia, a study
of social phobia and related social-anxiety traits, and studies of several other phenotypes.
We have ongoing collaborations with investigators at the Chulalongkorn Faculty of Medicine
in Bangkok, Thailand, to study genetics of substance dependence; and a collaborative
training program with that institution, to train Thai investigators in substance dependence
genetics at Yale.
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| Area of Expertise: | |
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Psychiatric genetics
Genetic linkage
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| Laboratory Personnel: | |
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Bau-zhu Yang, PhD, Associate Research Scientist
Xingguang Luo, M.D, Associate Research Scientist
Huiping Zhang, PhD, Postdoctoral Associate
Chupong Ittiwut, Postgraduate Fellow
Jennifer Listman, Postgraduate Fellow
Yari Nunez, SSADDA Interviewer
Matthew Madura, SSADDA Interviewer
Thomas Hudak, SSADDA Interviewer
Elizabeth Trainor, SSADDA Interviewer
Ellen Koucky, SSADDA Interviewer
Ann Marie Wantroba, MS, Technician
Greg Kay, Technician
Yakov Lozovatsky, Technician
Lisa Naito, Technician
Judy Smith, Senior Administrative Assistant
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| Achievements and Honors | |
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* NIH Medical Staff Fellowship
* NIMH Level I Career Award; NIMH Independent Scientist Career Award
* Member, American College of Neuropsychopharmacology
* Editorial Board member, Biological Psychiatry and Psychiatric Genetics
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| Representative Publications: | |
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| Zhang H, Luo X, Kranzler HR, Lappalainen J, Yang BZ, Krupitsky E, Zvartau E, Gelernter J: Association between two ? opioid receptor gene (OPRM1) haplotype blocks and drug or alcohol dependence Human Molecular Genetics 2006;15:807-819; doi:10.1093/hmg/ddl024
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Gelernter J, Panhuysen C, Wilcox M, Hesselbrock V, Rounsaville B, Poling J, Weiss R, Sonne S, Zhao H, Farrer L, and Kranzler HR: Genomewide linkage scan for opioid dependence and related traits. Am J Hum Genet 2006;78:759-769
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Luo X, Kranzler HR, Zuo L, Wang S, Schorck NJ, and Gelernter J: Diplotype trend regression (DTR) analysis of the ADH gene cluster and ALDH2 gene: Multiple significant associations for alcohol dependence. Am J Hum Genet 2006;78:973-987
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Kaufman J, Yang B-Z, Douglas-Palumberi H, Crouse-Artis M, Lipschitz D, Krystal JH, and Gelernter J: Genetic and Environmental Predictors of Early Alcohol Use. Biological Psychiatry (In press) 2006 Nov 20; [Epub ahead of print] PMID: 17123474
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Gelernter J, Panhuysen C, Weiss R, Brady K, Poling J, Krauthammer M, Farrer L, and Kranzler HR: Genomewide linkage scan for nicotine dependence: Identification of a chromosome 5 risk locus. Biological Psychiatry. 2007; 61:119-126. Published online Nov. 1, 2006
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Gelernter J, Yu Y, Weiss R, Brady K, Panhuysen C, Yang BZ, Kranzler HR, and Farrer L: Haplotype Spanning TTC12 and ANKK1, Flanked By the DRD2 and NCAM1 Loci, is Strongly Associated to Nicotine Dependence in Two Distinct American Populations. Human Molecular Genetics 2006;15,3498–3507 doi:10.1093/hmg/ddl426
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Luo X, Kranzler HR, Zuo L, Wang S, Schork NJ, and Gelernter J: Multiple ADH genes modulate risk for drug dependence in both African- and European-Americans. Human Molecular Genetics 2007;16:380-390; doi:10.1093/hmg/ddl460
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Stein MB, Schork NJ, and Gelernter J: Gene-by-Environment (Serotonin Transporter and Childhood Maltreatment) Interaction for Anxiety Sensitivity, an Intermediate Phenotype for Anxiety Disorders. Neuropsychopharmacology. 2007 Apr 25; [Epub ahead of print] PMID: 17460615
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Luo X, Kranzler HR, Zuo L, Zhang H, Wang S, and Gelernter J: CHRM2 variation predisposes to personality traits of agreeableness and conscientiousness. Hum Mol Genet. 2007 Apr 27; [Epub ahead of print] PMID: 17468496
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Listman J, Malison RT, Sughondhabirom A, Thavichachart N, Kranzler HR, Tangwonchai S, Mutirangura A, Disotell TR, and Gelernter J: Population differentiation of an East Asian isolate from major East Asian populations using 36 microsatellites. BMC Genetics 2007, 8:21
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Zhang H, Kranzler HR, Yang B-Z, Luo X, and Gelernter J: The OPRD1 and OPRK1 loci in alcohol or drug dependence: OPRD1 variation modulates substance dependence risk Molecular Psychiatry (In press)
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Kilpatrick DG, Koenen KC, Ruggiero KJ, Acierno R, Galea S, Resnick HS, Roitzsch J, Boyle J, and Gelernter J: Serotonin transporter genotype and social support moderate posttraumatic stress disorder and depression in hurricane-exposed adults. American Journal of Psychiatry (In press)
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| Contact Information | |
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Joel Gelernter, MD
Professor of Psychiatry, Genetics, and Neurobiology
Director, Division of Human Genetics in Psychiatry
VA Medical Center
Tel: 203-932-5711 x3590
Fax: 203-937-3897
Email: joel.gelernter@yale.edu
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