Publications
Lee, K.H., Park, K.H., Lee, H.J.,
Hwang, E.S., Suh, H.C., Oh, B.H., and Jang,
H.D. (1984) Characteristics of two yeast strains and conditions
for the protoplast formation and regeneration as a preliminary
step in interspecific protoplast-fusion. Seoul Nat'l University,
College of Agriculture Research 9:1-16.
Milman, G. and Hwang,
E.S. (1987) Epstein-Barr virus nuclear antigen forms
a complex that binds with high concentration dependence to a
single DNA-binding site. J. Virol. 61:465-
Hwang, E.S.
and Scocca, J.J. (1990) Interaction of integration host factor
from escherichia coli with the integration region of the haemophilus
influenzae bacteriophage HP1. J. Bacteriol. 172:4852-4860.
Yuan, Y., Hwang,
E.S., and Altman, S. (1992) Targeted cleavage of messenger
RNA by human RNaseP. Proc. Natl. Acad. Sci. USA 89:8001-8005.
Hwang, E.S.
and Scocca, J.J. (1993) A method of cloning multiple direct
repeats of DNA segment. Biotechniques 14:766-767.
Hwang, E.S.,
Riese, II, D.J., Settleman, J., Nilson, L., Honig, J., Flynn,
S., and DiMaio, D. (1993) Inhibition of cervical carcinoma cell
line proliferation by introduction of a bovine papillomavirus
regulatory gene. J. Virol. 67:3720-3729.
DiMaio, D., Petti, L., and
Hwang, E.S. (1994) The E5 transforming proteins
of the papillomaviruses. Sem. Virol. 5:369-379.
Hwang, E.S.,
Nottoli, T., and DiMaio, D. (1995) The HPV16 E5 protein: expression,
detection, and stable complex formation with trans-membrane
proteins in cos cells. Virology 211:227-233.
Seo, J., Park, W., Kim, J.S.,
Hwang, E.S., Lee, J.-H., and Hong, S.H. (1995)
Endogenous gene expression of p53 and regulatory subunits of
cyclic AMP-dependent protein kinase in ovarian cancer cells.
Korean J. Zool. 38:204-211.
Hwang, E.S.,
Naeger, L.K., and DiMaio, D. (1996) Activation of endogenous
growth inhibitory pathways in HeLa cervical carcinoma cells
by expression of the bovine papillomavirus E2 gene. Oncogene
12:795-803.
Park, J.S., Hwang,
E.S., Ahn, H.K., Kim, C.J., Chung, K.T., Kim, H.S.,
Park, S.N., Namkoong, S.E., and Kim, S.J. (1996) Seroreactivities
to HPV-16 virus like particles (VLPs) using ELISA in the patients
with cervical neoplasia. Korean J. Gynecol. 39:176-185.
Park, W., Choi, J.-J., Hwang,
E.S., Lee, J.-H. (1996) Identification of a variant
estrogen receptor lacking Exon4 and its coexpression with wild-type
estrogen receptor in ovarian carcinomas. Clin. Cancer Res.
2:2029-2035.
Park, J.S., Hwang,
E.S., Park, S.N., Ahn, H.K., Yang, H.K., Kim, C.J.,
Kim, S.J., and Namkoong, S.E. (1997) Physical status and expression
of HPV genes in cervical cancers. Gynecol. Oncol. 65:121-129.
Kim, S.N., Lee, G.R., Hwang,
E.S., Lee, J.-H., Park, S.D., Cho-Chung, Y.S., and
Hong, S.H.. (1997) Type II protein kinase A up-regulation is
sufficient to induce growth inhibition in SK-N-SH human neuroblastoma
cells. Biochem. Biophy. Res. Com. 232:469-473.
Hwang, E.S.,
Kim, J., Kim, J.S., Ko. S.C., Chung, L., and J.-H. Lee. (1998)
The effects of the adenovirus-mediated wild-type p53 delivery
in human ovarian cancer cell lines in vitro and in vivo.
Intl. J. Gynecol. Cancer 8:27-36.
Park, J.S., Um, S.J.,
Hwang, E.S., Park, S.N., Ahn, H.K., Kim, C.J., and
Namkoong, S.E.. (1998) Immunresponse to p53 and HPV16 E6 proteins
in patients with cervical cancer. Intl. J. Gynecol. Cancer
8:542-547.
Hwang, E.S.
(1998) Induction of senescence-like state in HeLa cells by the
expression of bovine papillomavirus E2 gene. Korean J. Gerontol.
8:57-65.
Kim, J., Hwang, E.S.,
Kim, J.S., Ryu, E.H., Lee, S.H., and Lee, J.-H. (1999) Intraperitoneal
gene therapy with adenoviral-mediated p53 tumor suppressor gene
for ovarian cancer model in nude mouse. Cancer Gene Ther.
6:172-178.
Kim, C.J., Um, S.J., Hwang,
E.S., Park, S.N., Kim, S.J., and Namkoong, S.E. (1999)
The antibody response to HPV proteins and genomic state of HPVs
in patients with cervical cancer. Intl. J. Gynecol. Cancer
9:1-11.
Naeger, L.K., Goodwin, E.C.,
Hwang, E.S., DeFilippis, R.A., Zhang, H., and
DiMaio, D. (1999) Bovine papillomavirus E2 protein activates
a complex growth-inhibitory program in p53-negative HT-3 cervical
carcinoma cells that includes repression of cyclin A and cdc25A
phosphatase genes and accumulation of hypophosphorylated retinoblastoma
protein. Cell Growth & Differentiation 10:1-10.
Park, J.S., Hwang,
E.S., Lee, C.J., Kim, C.J., Rha, J.G., Namkoong, E.S.,
and Um, S.J. (1999) Mutational and functional analysis of HPV16
URR derived from Korean cervical neoplasia. Gynecol. Oncol.
74:23-29.
Hwang, E.S.
(1999) Cellular machineries that regulate p53 tumor suppressor
activity. Biochemistry News 19:194-201.
Goodwin, E.C., Yang, E.,
Lee, C.J., Lee, H.W., DiMaio, D., and Hwang, E.S.
(2000) Rapid Induction of senescence in human cervical carcinoma
cells. Proc. Natl. Acad. Sci. USA 97:10978-10983.
Lee, C.-J., Lee, J.-Y., Song,
Y.-S., and Hwang, E.S. (2000) Endothelin-1
autocrine is suppressed in HeLa cells induced to a senescent
state. Korean J. Gerontol. 10:31-37.
Um, S.J., Kim, E.J.,
Hwang, E.S., Kim, S.J., Namkoong, S.E., and Park, J.S.
(2000) Antiproliferative effects of retinoic acid/interferon
in cervical carcinoma cell lines:cooperative growth suppression
of IRF-1 and p53. Intl. J. Cancer. 85:416-423.
Park, J.S., Kim, E.J., Kwon,
H.J., Hwang, E.S., Namkoong, S.E., and Um,
S.J. (2000) Inactivation of Interferon regulatory factor-1 tumor
suppressor protein by HPV E7 oncoprotein. J. Biol. Chem.
275:6764-6769.
Lee, C.J., Lee, J.-Y., Song,
Y.-S., and Hwang, E.S. (2000) Endothelin-1
autocrine is suppressed in HeLa cells induced to a senescent
state. Korean J. Gerontol. 10:31-37.
Moon, M.S., Lee, C.J., Um,
S.J., Park, J.S., Yang, J.M., and Hwang, E.S..
(2001) Effect of BPV1 E2-mediated inhibition of E6/E7 expression
in HPV16-positive cervical carcinoma cells. Gynecol. Oncol.
80:168-175.
Um, S.-J., Rhyu, J.-W., Kim,
E.-J., Jeon, K.-C., Hwang, E.S., and Park,
J.-S. (2002) Abrogation of IRF-1 response by high-risk HPV E7
protein in vivo. Cancer Letters 179:205-212.
Lee, C.J., E.J. Suh, Kang,
H.T., Im, J.S., Um, S.J., Park, J.S., and Hwang, E.S..
(2002) Induction of senescence-like state and suppression of
telomerase activity through inhibition of HPV E6/E7 gene expression
in cells immortalized by HPV16 DNA. Exp. Cell Res. 77:173-82.
Shin, K.-S., Bae, S.-J.,
Hwang, E.S., Jeong, S., and Lee, S.-W. (2002)
Ribozyme-mediated replacement of p53 RNA by targeted trans-splicing.
J. Microbiol. Biotechnol. 12:844-848.
Hwang, E.S.
(2002) Replicative senescence and senescence-like state induced
in cancer-derived cells. Mech. Ageing Dev. 123:1681-1694.
Lee, B.Y. and Hwang,
E.S. (2002) Induction of senescence phenotypes in cancer
cells by an acute growth arrest followed by ROS stress. Korean
J. Gerontol. 12:31-39.
Kim, J., Lee, D., Hwang,
S.G., Hwang, E.S., and Choe, J. (2003) BRCA1
associates with human papillomavirus type18 E2 and stimulates
E2-dependent transcription. Biochem. Biophys. Res. Comm.
305:1008-1016.
Kang, H.T., Ju, J.W., Cho,
J.W., and Hwang, E.S. (2003) Downregulation
of Sp1 activity through modulation of O-glycosylation by treatment
with a low glucose mimetic, 2-deoxyglucose. J. Biol. Chem.
278:51223-51231.
Kang, H.T., Lee, C.J., Seo,
E.J., Bahn, Y.J., Kim, H.J., and Hwang, E.S. (2004)
Transition to an irreversible state of senescence in HeLa cells
arrested by repression of HPV E6 and E7 genes. Mech. Ageing
Dev. 125:31-40.
Hwang, E.S. (2004) Mechanism of aging and modulation of aging
at cellular level. J. Korean Soc. Endocrinol. 19:90-93.
Seo, E.J., Kim, H.J., Lee,
C.J., Kang, H.T., and Hwang, E.S.. (2004) The
role of HPV oncoproteins and cellular factors in maintenance
of hTERT expression in cervical carcinoma cells. Gynecol.
Oncol. 94:40-47.
Sook, Y.S., Lee, B.Y., and
Hwang, E.S. (2005) Dinstinct ROS and biochemical
profiles in cells undergoing DNA damage-induced senescence and
apoptosis. Mech. Ageing Dev. 126:580-590.
Tang, H.T. and Hwang,
E.S. (2005) 2-Deoxyglucose: an anti-cancer and anti-viral
therapeutic, but not any more a low-glucose mimetic. Life
Sci. (In press).
Lee, B.Y., Han, J.A., Lim,
J.S., Morrone, A., Johung, K., Goodwin, E.C., Keijer, W., DiMaio,
D.*, and Hwang, E.-S.* (2006) Senescence-associated
ß-galactosidase is lysosomal acid ß-galactosidase.
Aging Cell 5: 187-195. (*corresponding authors)
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