Project
Control of Gene Expression during
Senescence Publications
Woychik, R.P., Camper, S.C., Lyons, R.H., Horowitz, S., Goodwin,
E.C., and Rottman, F.M. (1982) Cloning and nucleotide
sequencing of the bovine growth hormone gene. Nucl. Acids
Res. 10:7197-7212.
Rottman, F.M., Campers,
S.C., Goodwin, E.C., Hampson, R.K., Lyons,
R.L., Sakai, D., Woychik, R.P., and Yao, Y. (1986) Structure
and Regulation of the Bovine Prolactin and Bovine Growth Hormone
Genes. In: Molecular and Cellular Aspects of Reproduction, Dhindsa,
D.S., and Bahl, O.P., eds. Plenum Publishing Corp., pp. 281-299.
Goodwin, E.C.
and Rottman, F.M. (1992) The use of Rnase H and poly(A) junction
oligonucleotides in the analysis of in vitro polyadenylation
reaction products. Nucl. Acids Res. 20:916.
Goodwin, E.C.
and Rotman, F.M. (1992) The 3’-flanking sequence of the
bovine growth hormone gene contains novel elements required
for efficient and accurate polyadenylation. J. Biol. Chem.
267:16330-16334.
Narayan, P., Ludwiczak,
R.L., Goodwin, E.C., and Rottman, F.M. (1994)
Context effects on N6-adenosine methylation sites in prolactin
mRNA. Nucl. Acids Res. 22:419-426.
Goodwin, E.C.,
Naeger, L.K., Breiding, D.E., Androphy, E.J., and DiMaio, D.
(1998) Transactivation-competent bovine papillomavirus E2 protein
is specifically required for efficient repression of human papillomavirus
oncogene expression and for acute growth inhibition of cervical
carcinoma cell lines. J. Virol. 72:3925-3934.
Naeger, L.K., Goodwin,
E.C., Hwang, E.S., DeFilippis, R.A., Zhang, H., and
DiMaio, D. (1999) Bovine papillomavirus E2 protein activates
a complex growth-inhibitory program in p53-negative HT-3 cervical
carcinoma cells that includes repression of cyclin A and cdc25A
phosphatase genes and accumulation of hypophosphorylated retinoblastoma
protein. Cell Growth & Differ. 10: 413-422.
Wu, L., Goodwin,
E.C., Naeger, L.K., Vigo, E., Galaktionov, K., Helin,
K., & DiMaio, D. (2000) E2F-Rb complexes assemble and inhibit
cdc25A transcription in cervical carcinoma cells following repression
of human papillomavirus oncogene expression. Mol. Cell.
Biol. 20:7059-7067.
Goodwin, E.C.,
Yang, E., Lee, C.-J., Lee, H.-W., DiMaio, D., and Hwang, E.-S.
(2000) Rapid induction of senescence in human cervical carcinoma
cells. Proc. Natl. Acad. Sci. USA 97:10978-10983.
Goodwin, E.C.
and DiMaio, D. (2000) Repression of human papillomavirus oncogenes
in HeLa cervical carcinoma cells causes the orderly reactivation
of dormant tumor suppressor pathways. Proc. Natl. Acad.
Sci. USA 97:12513-12518.
Goodwin, E.C.
and DiMaio, D. (2001) Induced senescence in HeLa cervical carcinoma
cells containing elevated telomerase activity and extended telomeres.
Cell Growth & Differ. 12:525-534.
DeFilippis, R.A., Goodwin,
E.C., Wu, L., and DiMaio, D. (2003) Endogenous human
papillomavirus E6 and E7 proteins differentially regulate proliferation,
senescence and apoptosis in HeLa cervical carcinoma cells. J.
Virol. 77:1551-1563.
Brandsma, J.L., Shlyankevich,
M., Zhang, L., Slade, M.D., Goodwin, E.C.,
Peh, W., and Deisseroth, A.B. (2004) Vaccination of rabbits
with an adenovirus vector expressing the papillomavirus E2 protein
leads to clearance of papillomas and infection. J. Virol.
78:116-123.
Lee, B.Y., Han, J.A., Lim, J.S., Morrone, A., Johung, K., Goodwin,
E.C., Keijer, W., DiMaio, D.*, and Hwang, E.-S.* (2006)
Senescence-associated ß-galactosidase is lysosomal acid
ß-galactosidase. Aging Cell 5: 187-195. (*corresponding
authors)
Johung, K., Goodwin, E.C., and DiMaio, D. (2007) Human papillomavirus E7 repression in cervical carcinoma cells initiates a transcriptional cascade driven by the retinoblastoma family, resulting in senescence. J. Virol. 81:2102-2116.
Nguyen, M., Kraft, R.M., Aubert, M., Goodwin, E.C., DiMaio, D., and Blaho, J. (2007) p53 and hTERT determine sensitivity to viral apoptosis. J. Virol. 81:12985-12995.
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