Yale Genetics

Molecular mechanisms of cancer predisposition and developmental defects; DNA diagnostics.

RNA transport, metabolism; molecular mechanisms of gene expression; hemoglobin.

Ultraviolet light and skin cancer; DNA repair.

Interoperating genomic databases using XML and building and integrating genomic data analysis tools.

Molecular genetics and pathophysiology of inflammatory bowel disease.

Molecular genetics of Drosophila oogenesis; actin cytoskeleton regulation.

Molecular biology of tumor viruses; mechanisms of viral carcinogenesis; molecular basis of cell growth regulation.

Molecular genetics of erythroid cell differentiation.

The research focus of my laboratory is genetics of psychiatric illness.

In our laboratory we use zebrafish as a model system to investigate the role of microRNAs during vertebrate development.

Gene targeting and gene therapy; Genetic instability in cancer; Mutagenesis; DNA repair; radiation resistance; cellular responses to radiation

We study the genetics and behavior of stem cells and their niches using the skin hair follicle as a model system.

Our lab is interested in finding and characterizing genes that cause dyslexia, and studying how variations of these genes affect brain development.

We study the genetics and cell biology of axon regeneration and degeneration using the model organism C. elegans.

Protein folding and misfolding in the cell - role of chaperonins in mediating protein folding; misfolding in neurodegeneration.

Molecular control of cell fate decisions in embryonic and somatic stem cells.

Establishment of vertebrate body plan and embryonic patterning. Developing Xenopus genetics to study gene regulatory networks.

Human polymorphism studies; population and behavioral genetics.

Discovery and analysis of transcriptional regulatory elements in normal and cancer genomes.

Cytogenetic and genomic analysis to dissect genetic mechanisms for growth regulation, mental development, and cancer progression.

Genetic and molecular determinants of cardiovascular and kidney disease.

Molecular genetic studies of neurodegenerative diseases.

Studying molecular mechanisms underlying the self-renewing division of stem cells.

We are interested in using genomics to understand the role of non-coding RNAs in mammalian development and disease.

Clinical genetics; diagnosis and therapy of human fetal disease.

Human evolution; evolutionary dynamics of gene regulation; synthetic biology; comparative and functional genomics in vertebrates.

Functional genomic analysis of global gene expression mechanisms; C. elegans germline development.

Meiotic chromosome behavior; cell cycle checkpoints.

Clinical genetics; inherited metabolic disorders.

Research directed toward understanding the mechanism of gene expression in human mitochondria and its impact on human aging and disease.

Genetics of ion transport.

Genetic causes of liver and kidney disease.

Identifying and characterizing genes and genetic mechanisms involved in neuropsychiatric disorders of childhood.

Kidney development, Polycystic kidney disease (PKD), Size control, Zebrafish genetics.

Genome stability, mutagenesis, DNA replication, DNA repair, carcinogenesis.

Molecular genetics of virus-host cell interactions.

Mouse genetics; developmental genetics underlying limb development and organogenesis.

Globin and histocompatibility gene structure and function; long-range DNA mapping; transcription factors; lymphocyte anergy; stem cells; cell senescence; methods for molecular genetics.

Molecular genetics of development and human diseases.

Developing mathematical, statistical, and numerical methods to address scientific questions raised in molecular biology and genetics.