Curtis L. Patton, Ph.D.
Professor,
Division of Epidemiology of
Microbial Diseases
Professor Patton's research interests include identification and
characterization of trypanosome specific calmodulin response elements,
as well as studies of structure and biological function of trypanosome
calmodulin. Under physiological conditions, treatment with methylating
agents induces synchronous differentiation in these parasites. In
his research Professor Patton is characterizing carboxyl methyltransferases
and methylesterases and determining the role of S-adenosyl-methionine
and decarboxylated S-adenosylmethionine in alpha-ifluoromethylornithine-induced
differentiation.
Selected Publications
Cobey, F.C., Goldbarg, S.H., Levine, R.A., and Patton, C.L. Detection
of borrelia (relapsing fever) in rural Ethiopia by means of
the quantitative buffy coat technique. American Journal of
Tropical Medicine & Hygiene 65: 164-5, 2001.
Ridgley, E., Webster, P., Ruben, L., and Patton, C. Calmodulin-binding
properties of the paraflagellar rod complex from Trypanosoma brucei.
Molecular and Biochemical Parasitology 109(2): 1995-201, 2000.
Penketh, P.G., Shyam, K, Patton, C.L. and Sartorelli, A.C. . Annals of Biochemistry 238: 46-49, 1996. Spectrophotometric
Assay for Processes Involving Changes in Hydrogen Ion Concentration
in Aqueous Solution
Edwards, A.J., Sweeny, P.J. Reid, D.G., Walker, J.M. Elshourbagy,
N., Young, J.F., Egwuagu, C.E. and Patton, C.L. Synthesis
and analysis of the enantiomers of calmidazolium and a 1H NMR demonstration
of a chiral interaction with calmodulin. Chirality 8(8): 545-550,
1996.
El-Sayed, N.M.A., Harkins, P.C., Fox, R.O., Anderson, K., and
Patton, C.L. Crystallization and Preliminary X-ray Investigation
of the Recombinant Trypanosoma brucei rhodesiense Calmodulin.
Proteins: Structure Function and Genetics 21: 354-357, 1995.
Divo, A.A., Patton, C. and Sartorelli, A.C. Evaluation of rhodamine
123 as a probe for monitoring mitochondrial function in Trypanosoma
brucei spp. Journal Eukaryotic. Microbiology 40: 329-335, 1993.
Penketh, P.G., Divo, A.A., Shyam, K., Patton, C.L. and Sartorelli,
A.C. The effects of methylating agent 1,2-bis(methylsulfonyl)-1-methylhydrazine
on morphology, DNA content and mitochondrial function of Trypanosoma
brucei subspecies. Journal of Protozoology 38: 172-177, 1991. |
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