Pilots

Past and Present Pilots/Feasibility Studies

P/F #1 "Cloning of Human Melanoma Suppressor Gene(s)." Joseph Germino, M.D., Ph.D. (Oncology) and Ruth Halaban, Ph.D. (Dermatology)

P/F #2 "Genetic Determinants of Fibropapilloma Formation in Bovine Skin" Daniel DiMaio, M.D./Ph.D. (Genetics), Janet Brandsma, Ph.D. (Comparative Medicine)

P/F #3 "Psoralen Mutagenesis." Francis Gasparro, Ph.D. (Dermatology) and Peter Glazer, M.D., Ph.D. (Therapeutic Radiology)

P/F #4 "Role of Epican in Cell-Cell Adhesion." Leonard Milstone, M.D. (Dermatology), Jeffrey Bender, M.D. (Cardiology)

P/F #5 "Myosin Isoforms in Epithelial Lymphocytes." Adrian Hayday, Ph.D. (Biology) and Robert E. Tigelaar, M.D. (Dermatology)

P/F #6 "Human Skin and T Cell Interactions in Scid Mice" - Philip Askenase, M.D. (Allergy), Jordan Pober, M.D./Ph.D. (Pathology)

P/F #7 "Investigation of Major Histocompatibility Complex Class I Antigen Processing in Activated T Cells: Possible Role of Class I Recycling" - Suguru Imaeda, M.D. (Dermatology), Charles Janeway, Jr., M.D.(Immunobiology)

P/F #8 "TGFbeta Receptors in Squamous Cell Carcinomas" - Michael Reiss, M.D. (Oncology) and David Stern, Ph.D. (Pathology)

P/F #9 "A New Cell Culture Model of Human Skin Cancer" - John Sedivy, Ph.D. (Molecular Biophysics and Biochemistry), Ruth Halaban, Ph.D. (Dermatology)

P/F #10 "Role of Macrophages in the Skin of Lyme-infected Mice" - Ruth Montgomery, Ph.D.(Rheumatology), Stephen Malawista, M.D. (Rheumatology), Stephen Barthold, D.V.M., Ph.D.(Comparative Medicine)

P/F #11 "PTH-rp Effect on Dermal Fibroblast IGF-1 Synthesis" - Michael Centrella, Ph.D. (Surgery) and Thomas McCarthy, Ph.D.(Surgery)

P/F #12 "Role of Calcitonin Gene Related Peptide in Skin" - Agnes Vignery, D.D.S., Ph.D. (Orthopedics), Jack Longley, MD (Dermatology)

P/F #13 "Gene targeting in normal human keratinocytes" Leonard Milstone, M.D. (Dermatology), John Sedivy, Ph.D. (Molecular Biophysics and Biochemistry)

P/F #14 "Molecular analysis of XP variant cells" Manidipa Raha, Ph.D. (Therapeutic Radiology) , Peter Glazer, M.D., Ph.D. (Therapeutic Radiology), Francis Gasparro, Ph.D. (Surgery)

P/F #15 "Experimental models for streptococcal impetigo" Debra Bessen, Ph.D. (Epidemiology and Public Health), Jennifer Madison, M.D. (Dermatology)

P/F #16 "Creation of Human Cell Lines Expressing 'Empty' MHC Class I Alleles at the Cell Surface" Peter Cresswell, Ph.D. (Immunobiology), Douglas Hanlon, Ph.D. (Dermatology)

P/F #17 "The role of protease factor Xa in melanoma cell growth and metastisis" - Michael Capello, M.D. (Pediatrics), Michael Bromberg, M.D., Ph.D. (Hematology)

P/F #18 "Overgrowth due to IGF1-like effects in the nevoid basal cell carcinoma syndrome" - Allen Bale, M.D. (Genetics), Thomas Carpenter, M.D. (Pediatrics), and David Leffell, M.D. (Dermatology)

P/F #19 "Local and Systemic Impact of Altered Skin Metabolism" - Pauline Schwartz, Ph.D. (Dermatology), Janet Brandsma, Ph.D. (Comparative Medicine)

P/F #20 "Role of TCR Repertoire in Determining Immunodominance" - Eric Pamer, M.D. (Infectious Diseases), Charles Janeway, M.D. (Immunobiology)

P/F #21 Endothelial Cell and Lymphocyte Adhesion Molecules in CTCL" Jeffrey Schechner, M.D. (Dermatology), Jordan Pober, M.D., Ph.D. (Pathology)

P/F #22 "Anti-tumor Immunization with DNA Plasmids Encoding T Cell Receptor Genes in a Murine Model of T Cell Lymphoma" Michael Girardi, M.D. (Dermatology), Robert Tigelaar, M.D. (Dermatology), Carole Berger, Ph.D. (Dermatology), Adrian Hayday (Biology) and Janet Brandsma (Comparative Medicine)

P/F #23 "Pathogenesis of Murine Lupus Dermatoses" Mark Shlomchik, M.D., Ph.D. (Laboratory Medicine), Jennifer McNiff, M.D. (Dermatology)

P/F #24 "The Effect Of Patched Mutations On Protein Trafficking: A Green Fluorescent Protein Study." Mae Gailani, M.D. (Pediatrics), Thomas Hughes, Ph.D. (Ophthalmology)

P/F #25 "Intracellular Binding Of Photoactivated 8-Methoxypsoralen And Augmentation Of The MHC Class I Antigen Processing Pathway" Douglas Hanlon, Ph.D. (Dermatology), Richard Edelson, M.D. (Dermatology)

P/F #26 "Role of ? Catenin Activation in the Progression and Prognosis of Melanoma" David Rimm, M.D., Ph.D. (Pathology), Ruth Halaban, Ph.D. (Dermatology)

P/F #27 "Th2-Mediated Cutaneous Inflammatory Responses Following Epicutaneous Sensitization To Soluble Protein" Christina Herrick, M.D., Ph.D. (Dermatology), Kim Bottomly, Ph.D. (Immunobiology)

P/F #28 -- "CTL Responses to Vaccination in the CRPV-Rabbit Model" Janet Brandsma, Ph.D. (Comparative Medicine), P.I. Robert E. Tigelaar, M.D., (Dermatology and Immunobiology), Co-Investigator

P/F #29 -- "Pathogenic mechanisms of GVHD in a murine model" Warren Shlomchik, M.D. (Oncology), P.I. Mark Shlomchik, M.D., Ph.D. (Laboratory Medicine) Collaborator

P/F #30 -- "Genomic mapping of replication origins in melanocytes and melanoma" Hisama, Fuki, M.D. (Neurology), P.I., Sherman Weissman, M.D. (Genetics), Collaborator, Ruth Halaban, Ph.D. (Dermatology), Collaborator

P/F #31 -- "Chemokine basis of skin-specific T cell homing" Martin Kluger, Ph.D. (Dermatology), P.I. Kim Bottomly, Ph.D. (Immunobiology), Collaborator, Michael Kasgarian, M.D. (Pathology), Collaborator, Jeffrey Schechner, M.D. (Dermatology), Collaborator, William Sessa, Ph.D. (Pharmacology), Collaborator

P/F #32 -- "Nucleoside phosphorylases: role in wound healing in skin" John Haggerty, Ph.D. (Dermatology), P.I., Pauline Schwartz, Ph.D. ((Dermatology), Co-Investigator, Martin Kluger, Ph.D. (Dermatology), Collaborator, Timothy Heath, Ph.D. (Pharmacuetics - U. Wisconsin), Collaborator

P/F #33 -- " Gamma delta T cells in chemically-induced fibrosarcomas" Zhinan Yin, (Rheumatology) P.I. ,Michael Girardi, (Dermatology) Collaborator

P/F #34 - " NK T cell-derived IL-4 activates B-1 cells in contact sensitivity" Philip Askenase, MD (Immunology), P.I. Jeffrey Schechner, M.D. (Dermatology), Collaborator

P/F #35 - "Association of the novel gene MYG1 to cancer" Yoel Smicun, Ph.D. (Dermatology), P.I. Mazin Qumsiyeh, Ph.D. (Genetics) Collaborator

P/F #36 -- "Borrelia burgdorferi Interaction with Human Skin" Linda Bockenstedt, M.D. (Rheumatology) P.I., Jennifer Madison McNiff , M.D. (Dermatology), Collaborator

P/F #37 - "Coarse Melanin in Human Melanoma" John Pawelek, PhD (Dermatology), P.I. Tamara Handerson, M.D. (Dermatology), Collaborator

P/F #38 - "The role of intracellular pH in tyrosinase maturation and melanocyte dedifferentiation." Edward Sergio Trombetta, Ph.D. (Cell Biology), P.I. Ruth Halaban, Ph.D. (Dermatology), Collaborator

P/F #39 - "Frequency of MIF gene polymorphism and cutaneous expression of MIF in patients with SLE" Insoo Kang, M.D., (Rheumatology), P.I. Richard, Bucala, M.D. (Pathology), Collaborator, Rossitza Lazova, M.D. (Dermatology), Collaborator

P/F #40 - "IL-20 expression and function in skin" Elizabeth Eynon, Ph.D. (Immunobiology), P.I. Robert Tigelaar, M.D. (Dermatology), Collaborator

P/F #41 - "Effect of tick saliva on polymorphonuclear leukocyte recruitment" Ruth Montgomery, Ph.D. (Rheumatology), P.I. Robert Homer, M.D.,Ph.D. (Pathology), Collaborator

P/F #42. -"Inhibitors of the dendritic cell MHC class II pathway: Effects on T-regulatory and cytotoxic cells in cutaneous T cell lymphoma"; Carole Berger, Ph.D. (Yale Dermatology), Principal Investigator; Peter Cresswell, Ph.D. (Yale Immunobiology), Collaborator.

P/F #43 - "Comprehensive analysis of E2F/retinoblastoma regulated genes in melanomas"; Deepak Narayan, M.D. (Yale Plastic Surgery), Principal Investigator; Sherman Weissman, M.D. (Yale Genetics) and Ruth Halaban, Ph.D. (Yale Dermatology), Collaborators.

P/F #44 "The Function of MEKK4 in Keratinocytes Exposed to Ultraviolet Light"; Richard Flavell, Ph.D. (Yale Immunobiology), Principal Investigator; Douglas Brash, Ph.D. (Yale Therapeutic Radiology), Collaborator.

P/F #45 - "The Role of Dermal Matrix in Vascular Remodeling"; Jeffrey Schechner, M.D. (Yale Dermatology), Principal Investigator; Kenneth Williams, Ph.D. (Yale Molecular Biophysics and Biochemistry, Keck Biotechnology Resource Laboratories), Collaborator.