Suguru Imaeda, M.D.

Assistant Professor of Dermatology

Research Interests

Identification of major histocompatibility complex class I (MHC I) associated tumor-specific peptides and immunomodulation of T cell tumors. 2) MHC I antigen processing and presentation in cutaneous T cell lymphoma (CTCL) cells. The research involves isolation, purification and characterization of MHC I self-peptides from a murine and human % cell lymphoma cell lines. Immunoaffinity purification, reversed phase high performance liquid chromatography (RP-HPLC), automated chemical sequencing and peptide synthesis have been used to identify and characterize octamer and nonamer self-peptides from a murine B cell lymphoma cell line. Similar techniques are used to isolate distinctive peptide antigens of CTCL cells and murine T cell tumors. The biological significance of isolated antigens is determined by cytotoxicity assays.

Education:	1984, B.A., Chemistry, Johns Hopkins University 1988, M.D., Albert Einstein College of Medicine
Training:	Fellowship: Yale University School of Medicine

Selected Publications

• Berger CL, Longley BJ, Imaeda S, Christensen I, Heald P, and Edelson RL. Tumor-specific peptides in cutaneous T cell lymphoma: association with class I MHLC and possible derivation from the clonotypic T cell receptor. Int J Cancer. In press.
• Duncan KO, Imaeda S, and Milstone LM. Pneumocystis carinii pneumonia complicating methotrexate treatment of pityriasis rubra pilaris. J Am Acad Dermatol. In Press 1998.
• Huether MJ, Bolognia JL, Imaeda S, and McNiff JM. Bullous pemphigoid associated with eosinophilic pustules. British J Dermatol 136: 641-642, 1997.
• Imaeda S. The evolution of anti-tumor immunotherapy (editorial). J Invest Dermatol. 108:695-697, 1997.
• Imaeda S, Felli A, Schmitt I, Chimenti S, and Edelson RL. Induction of functional empty class I major histocompatibility complex glycoproteins by photoactivated 8-methoxypsoralen. J Invest Dermatol 107: 887-890, 1996.
• Shepherd JC, Schumacher TNM, Ashton-Rickardt PG, Imaeda S, Ploegh HL, Janeway CA, Tonegawa S. TAP1-dependent peptide translocation in vitro is ATP dependent and peptide selective. Cell 74:577-584, 1993.

Lab Personnel

• Ines Rashkovsky, M.D., Postdoctoral Research Fellow
• Dennis Chen, Research Assistant

Contact

Mailing Address
Yale School of Medicine
333 Cedar Street
New Haven, CT 06520-8059

Office Address
Yale Dermatology Associates, P.C.
2 Church Street South, Suite 305
New Haven, CT 06519

E-mail
suguru.imaeda@yale.edu

Office Phone
(203) 785-4092