Yale School of Medicine

Dermatology

Dermatology, Yale School of Medicine

Dermatology
PO Box 208030
New Haven, CT 06520-8030

Earl John Glusac, M.D.

Earl John Glusac, M.D.

Professor of Pathology and Dermatology Yale University School of Medicine

Research Interests

Morphologic and immunohistochemical features of cutaneous lymphoproliferative, fibrohistiocytic, and melanocytic neoplasms.

Education:
 1982, B.A., English, University of Michigan
1987, M.D., Michigan State University
Training:
 Fellowship: Stanford University (Dermatopathology)

Selected Publications

  • Swanson PE, Fitzpatrick MM, Ritter JH, Glusac EJ, Wick MR. Immunohistologic differential diagnosis of basal cell carcinoma, squamous cell carcinoma, and trichoepithelioma in small cutaneous biopsy specimens. J Cutan Pathol 25: 153-159, 1998.
  • Bolognia JL, Glusac EJ. Hypopigmented common blue nevi. Arch Dermatol 134: 754-756, 1998.
  • McNiff JM, Schechner JS, Crotty PL, Glusac EJ. Mycosis Fungoides palmaris et plantaris or acral pagetoid reticulosis? Am J Dermatopathol. 20(3): 271-275, 1998.
  • Krasnoff J, Glusac EJ, Bolognia JL. Bubble hair-a possible explanation for its distribution. International J Dermatol 37: 378-385, 1998.
  • Glusac EJ, McNiff JM. Epithelioid Cell Histiocytoma: A Simulant of Vascular and MelanocyticNeoplasms. Am J Dermatopathol 21: 1-7, 1999
  • McNiff JM, Glusac EJ, Lazova R, Carroll CB. Morphea limited to the superficial reticular dermis: An under recognized histologic phenomenon. Am J Dermatopathol 21(4): 315-319, 1999.
  • McNiff JM, Eisen RN, Glusac EJ. Immunohistochemical comparison of cutaneous lymphadenoma, trichoblastoma, and basal cell carcinoma: Support for classification of lymphadenoma as a variant of trichoblastoma. J Cutan Pathol 26: 119-124, 1999.
  • Madsen JA, Tallini G, Glusac EJ, Salem R, Braverman I, Robert ME. Biliary tract obstruction secondary to mycosis fungoides: A case report. J Clin Gastroenterol 28(1): 56-60, 1999.
  • Girardi M, Glusac EJ, Imaeda S. Subcutaneous Fusarium Foot Abscess in a Renal Transplant Patient. Cutis 63: 267-270, 1999
  • Smoller BR, Bishop K, Glusac E, Kim YH, Hendrickson M. Reassessment of histologic parameters in the diagnosis of mycosis fungoides. Am J Surgical Pathology, 1995, 19:1423-1430.
  • Smoller BR, Bishop K, Glusac El, Bhargava B. Kim YH. Warnke RA. Reassessment of lymphocyte immunophenotyping in the diagnosis of patch and plaque stage lesions of mycosis fungoides. J Applied lmmunohistochemistry, 1995, 3:32-36.
  • Smoller BR, Bishop K, Glusac EJ, Bhargava B. Kim YH, Warnke RA. Lymphocyte antigen abnormalities in inflammatory dermatoses. J Applied Immunohistochemistry, 1995, 3:127-131.
  • Histologic Mimics of Cutaneous Lymphoma Pathology Annual, v. 30, part I, 1995, 1'3-141. Smeller BR. Glusac EJ.
  • Glusac EJ, Barr RJ. Everett MA, Pitha J. Santa Cruz DJ. Epithelioid cell histiocytoma: a report of ten cases including a new cellular variant Am J Surgical Pathology, 1994, 18(6):583-590.
  • Glusac EJ, Kindel, SE, Soslow RA, Smoller BR. Evaluation of Classical Architectural Criteria in Non-Mycosis Fungoides Cutaneous Lymphomas. Am J Dermatopathol, 1997, 19:557-561.
  • Glusac EJ, McNiff JM. Epithelioid cell histiocytoma, a simulant of vascular and melanocytic neoplasms. Am J Dermatopathol. 1991; 21: 1-7.
  • Hui P, Perkins AS, Glusac EJ. Assessment of clonality in melanocytic nevi. J Cutan Pathology 2001; 28: 140-144.
  • Glusac EJ. Under the microscope: doctors, lawyers and melanocytic neoplasms. (Invited Editoria and Review). J Cutan Pathology 2003; 30: 287-293.
  • Glusac EJ. Criterion by criterion, mycosis fungoides. Am J Dermatopathol 2003; 25: 264-269.
  • Bhattacharjee P, Glusac EJ. Langerhans cell hyperplasia in scabies: a mimic of Langerhans cell histiocytosis. J Cutan Pathology 2007; 34:716-720

Reviews, Chapters

  • Glusac EJ. Protothecosis. In: Emedicine Online Textbook of Dermatology. Williams James, Thomas Habif, editors, 1999.
  • Glusac EJ. Pseudolymphoma. In: Emedicine Online Textbook of Dermatology. Williams James, Thomas Habif, editors, 1999.
  • Glusac EJ. Angiolymphoid Hyperplasia with Eosinophilia. In: Emedicine Online Textbook of Dermatology. Williams James, Thomas Habif, editors, 1999.
  • Glusac EJ. Lymphocytoma Cutin. In: Emedicine Online Textbook of Dermatology. Williams James, Thomas Habif, editors, 1999.
  • Glusac EJ, Shapiro PE, McNiff JM. Cutaneous T-cell lymphoma: Refinement in the application of controversial histologic criteria. Dermatologic Clinics, 17(3): 601-614, 1999.
  • Girardi M, Glusac EJ, Imaeda S. Subcutaneous fusarium foot abscess in a renal transplant patient. Cutis 63: 267-270, 1999.
  • Olhoffer IH, Davidson D, Longley J, Glusac EJ, Leffell D. Bowenoid papulosis secondary to HPV16 limited to the face. British Journal of Dermatology (in press) 1999.
  • Lazova R, McNiff JM, Glusac AJ. Under the Microscope: Surgeons, pathologists and melanocytic nevi. Clinics in Plastic Surgery. In press 2000.
  • Heald P, Glusac EJ. Unilesional cutaneous T-cell lymphoma: clinical features, therapy, and follow-up of ten patients with a treatment-responsive mycosis fungoides variant. Journal American Academy of Dermatology 2000; 42: 283-285.
  • McGovern TW, Grossman D, Fitzgerald D, Glusac EJ, Leffell DJ. Status of residual tumor in patients with squamous cell carcinoma referred for mohs microscopically controlled surgery. Archives of Dermatology 1999; 135:1557-1559.
  • Thayu M, Tallini G, Glusac EJ, Kacinski BM, Wilson LD. Evaluation of T-cell receptor gene rearrangements in patients with recurrent patch/plaque (T2) CTCL (mycosis fungoides). Yale Journal of Biology & Medicine 1999; 72:365-375.
  • Herrick CA, MacLeod H, Glusac EJ, Tigelaar RE, Bottomly K. Th2 responses induced by epicutaneous versus inhalational protein exposure are differentially dependent on IL-4. Journal of Clinical Investigation 2000; 105: 765-775.
  • Hui P, Perkins AS, Glusac EJ. Assessment of clonality in melanocytic nevi. Journal of Cutaneous Pathology 2001; 28:140-144.
  • Huynh PM, Glusac EJ, Bolognia JL. Pointillist nevi. Journal of the American Academy of Dermatology 2001; 45: 397-400.
  • Berger CL, Xu A, Hanlon D, Lee C, Schechner J, Glusac E, Christensen I, Snyder D, Holloway V, Tigelaar R, Edelson RL. Induction of human tumor-loaded dendritic cells. International Journal of Cancer 2001; 91: 438-447.
  • Schaffer JV, Glusac EJ, Bolognia JL. The eclipse nevus; tan center with stellate brown rim. British Journal of Dermatology 2001; 145: 1023-1026.
  • Girardi M, Oppenheim DE, Steele CR, Lewis JM, Glusac EJ, Filler R, Hobby P, Sutton B, Tigelaar RE, Hayday AC Regulation of cutaneous malignancy by gamma delta T cells. Science 2001; 294:605-609.
  • Hui P*, Glusac EJ*, Sinard JH, Perkins AS. Clonal analysis of cutaneous fibrous histiocytoma (dermatofibroma). Journal of Cutaneous Pathology 2002; 29:385-389. *co-first authors
  • Girardi M, Lewis J, Glusac E, Filler RB, Geng L, Hayday AD, Tigelaar RE. Resident skin-specific T cells provide local, nonredundant regulation of cutaneous inflammation. Journal of Experimental Medicine 2002; 195: 855-867.
  • Willey A, Glusac EJ, Bolognia JL. Photoeruption in a patient treated with capecitabine (Xeloda) for metastatic breast cancer. Journal of the American Academy of Dermatology 2002; 47: 453.
  • Pol-Rodriquez MM, Crane S, Feinberg DL, Glusac EJ, Bolognia JL. Retiform Purpura: cryoglobulinemia associated with multiple myeloma. Archives of Dermatology 2003; 139: 803-808.
  • Huynh PM, Glusac EJ, Alvanez-Franco M, Berwick M, Bolognia JL. Numerous small darkly pigmented melanocytic nevi: The cheetah phenotype. Journal of the American Academy of Dermatology 2003; 48:707-713.
  • Balfour EM, Glusac EJ, Heald P, Talley LL, Smoller BR. Sezary syndrome: cutaneous immunoperoxidase double-labeling technique demonstrates CD4/CD8 ratio non-specificity. Journal of Cutaneous Pathology 2003; 30: 437-442.
  • Silverman JS. Glusac EJ. Epithelioid cell histiocytoma - histogenetic and kinetics analysis of dermal microvascular unit dendritic cell subpopulations. Journal of Cutaneous Pathology 2003; 30: 415-422.
  • Girardi M, Glusac EJ, Filler RB, Roberts SJ, Brzonova I, Lewis J, Tigelaar RE, Hayday AD. The distinct contributions of murine TCR gd+ and TCR ab+ T cells to different stages of chemically-induced skin cancer. The Journal of Experimental Medicine 2003: 198: 747-755.
  • Lambert EM, Leibling A, Glusac EJ, Antaya RJ. Henoch-Schonlein purpura following a meningococcal vaccine. Pediatrics 2003; 112: e491-494.
  • Li N, Kim JH, Glusac EJ. Brainstem involvement by mycosis fungoides in a patient with large-cell transformation: a case report and review of literature. Journal of Cutaneous Pathology 2003; 30: 326-331.
  • McNiff JM, Glusac EJ. Histologic features of melanocytic nevi seen in association with mycosis fungoides. Journal of Cutaneous Pathology 2003; 30: 606-610.
  • Smith BD, Glusac EJ, McNiff JM. Smith GL, Heald PW, Cooper DL, Wilson LD. Primary cutaneous B-cell lymphoma treated with radiotherapy: a comparison of the European Organization for Research and Treatment of Cancer and the World Health Organization classification systems. Journal of Clinical Oncology 2004; 22:634-639.
  • Huynh PM, Glusac EJ, Bolognia JL. The clinical appearance of clonal nevi (inverted type A nevi). International Journal of Dermatology 2004; 43: 882-885.
  • Girardi M, Oppenheim D, Glusac EJ, Filler R, Balmain A, Tigelaar RE, Hayday AC. Characterizing the protective component of the alpha/beta T cell response to transplantable squamous cell carcinoma. Journal of Investigative Dermatology 2004; 122” 699—706.
  • Bhattacharjee P, Glusac EJ. Early histopathologic changes in purple glove syndrome. Journal of Cutaneous Pathology 2004; 31: 513-515.
  • Borue X, Lee S, Grove J, Herzog EL, Harris R, Diflo T, Glusac E, Hyman K, Theise N, Krause D. Bone marrow derived stem cells contribute to epithelial engraftment during wound healing. American Journal of Pathology 2004; 165: 1767-1772.
  • Ma L, Glusac EJ. Fatal Subcutaneous Panniculitis-like T-cell Lymphoma (SPTCL) with Interface Change and Dermal Mucin, a Dead-Ringer for Lupus Erythematosus Journal of Cutaneous Pathology 2005: 360-365.
  • McNiff JM, Subtil A, Cowper S, Lazova R, Glusac EJ. Cellular digital fibromas: Distinctive CD34+ lesions that may mimic dermatofibrosarcoma protuberans. Journal of Cutaneous Pathology 2005; 32: 413-418.
  • Lazova R, Lester B, Glusac EJ, Handerson T, McNiff J. The characteristic histopathological features of nevi on and around the ear. Journal of Cutaneous Pathology 2005; 32: 40-44.
  • Glusac EJ. More lessons from lumps: It was muscular and packed (in) a punch. The American Journal of Dermatopathology 2005; 27: 268-271.
  • McNiff JM, Cowper SE, Lazova R, Subtil A, Glusac EJ. CD56 Staining in Merkel cell carcinoma and natural killer cell lymphoma: Magic bullet, diagnostic pitfall, or both? Journal of Cutaneous Pathology 2005; 32:541-545.
  • Pimpinelli N, Olsen EA, Santucci M, Vonderheid E, Haeffner AC, Stevens S, Burg G, Cerroni L, Dreno B, Glusac E, Giutart J, Heald PW, Kempf W, Knobler R, Lessin S, Sander C, Smoller BS, Telang G, Whittaker S, Iwatsuki K, Obitz E, Takigawa M, Turner ML, Wood GS. Defining early mycosis fungoides. Journal of the American Acacemy of Dermatology 2005: 1053-1063.
  • Dotto JE, Glusac EJ. p63 is a useful marker for cutaneous spindle cell squamous cell carcinoma. Journal of Cutaneous Pathology (in press)
  • Glusac EJ, Shapiro PE. Noninfectious granulomas. In: Elder D, ed. Lever’s Histopathology of the Skin. 9th ed. Philadelphia: Lippincott, 2004: 373-399.
  • Calonje E, Blessing K, Glusac EJ, Strutton G. Blue Naevi. In: World Health Organization Classification of Skin Tumors. LeBoit PE, Burg G, Weedon D, Sarasin A, Eds. Lyon: IARCPress, 2006: 95-96.
  • Weyers W, Mentzel T, Kasper RC, Tosti A, Iorizzo M, Zelger B, Caputo R, Kamino H, Harvel JD, Galinier P, Kao GF, Glusac EJ. Berti E, Weedon D, Rose C. Fibrous, fibrohistiocytic and histiocytic tumours. In: World Health Organization Classification of Skin Tumors. LeBoit PE, Burg G, Weedon D, Sarasin A, Eds. Lyon: IARCPress, 2004: 255-262.
  • Sangueza OP, Kasper RC, LeBoit P, Calonje E, Lee KC, Chan JKC, Sanchez-Carpintero I, Mihm MC Jr, Smith KJ, Skelton HG, Glusac EJ, Kao GF, North PE, Weedon D. Vascular tumors. In: World Health Organization Classification of Skin Tumors. LeBoit PE, Burg G, Weedon D, Sarasin A, Eds. Lyon: IARCPress, 2004: 233-246.
  • McNiff J, McCalmont TH, Requena L, Sangueza OP, Vassallo C, Rosso R, Borroni G, Glusac EJ, Pichardo RO. Benign tumors with apocrine and eccrine differentiation. In: World Health Organization Classification of Skin Tumors. LeBoit PE, Burg G, Weedon D, Sarasin A, Eds. Lyon: IARCPress, 2006: 139-148.
  • Glusac EJ, Shapiro PE, McNiff JM: Cutaneous T-cell lymphoma: refinement in the application of controversial histologic criteria. Dermatologic Clinics 1999; 17:601-614.
  • Lazova R, McNiff JM, Glusac EJ. Under the Microscope: Surgeons, pathologists and melanocytic nevi. Clinics in Plastic Surgery 2000 27:323-330.
  • Glusac EJ: Of Cells and architecture: New approaches to old criteria in mycosis fungoides. (Invited Editorial and Review) Journal of Cutaneous Pathology 2001; 28:169-173.
  • Girardi M, Schechner J, Glusac E, Berger C, Edelson R. Transimmunization and the evolution of extracorporeal photochemotherapy. Transfusion and Apheresis Science 2002; 26: 181-190.
  • Glusac EJ. Under the microscope: doctors, lawyers and melanocytic neoplasms. (Invited Editorial and Review) Journal of Cutaneous Pathology 2003; 30: 287-293.
  • Glusac EJ. Criterion by criterion, mycosis fungoides. The American Journal of Dermatopathology 2003; 25: 264-269.
  • Glusac EJ. What to call the LEJC-BFV nevus? (Invited Editorial) Journal of Cutaneous Pathology 2004; 31: 521-522.
  • Glusac EJ. The histologic diagnosis of early mycosis fungoides: frequent problems, sporadic solutions. Giornale Italiano di Dermatologia e Venereologia 2005; 140: 407-416.

 

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