Mouse Metabolic Phenotyping
Affiliation: Yale department |
 |
Overview
The Yale Mouse Metabolic Phenotyping Center provides in vivo and in vitro techniques to assess metabolic alterations in transgenic mice.
Description of services
- In Vivo Metabolism Core: Performs glucose-insulin clamps to assess insulin action and energy metabolism in liver and skeletal muscle of awake mice.
- In Vitro Metabolism Core: Performs phenotyping tests on isolated perfused organs (heart, liver, skeletal muscle, pancreatic beta cells) using both stable and radioactive tracer methodology in conjunction with GC/MS and NMR spectroscopic analysis.
- MRS/MRI Core: Performs noninvasive measurements of intracellular metabolites in muscle, liver and brain of transgenic mice using 13C/31P/1H MR spectroscopy as well as whole body measurement of fat and muscle tissue with MRI.
- The Analytical Core: provides GC-MS and LC/MS/MS analysis of plasma and tissue samples obtained from protocols performed in the In Vivo, MRS/MRI and the In Vitro Metabolic Cores.
- The Animal Core: provides a centralized facility for coordinating receiving, screening and monitoring mice from investigators.
Order on-line: http://mouse.yale.edu/order.html
Research Facilities
Information Technology
Library Resources
Related Offices
Institutional Review Boards
Other related links
Business Office
Tel: 203.737.5307
Fax: 203.785.5397
YALE UNIVERSITY
SCHOOL OF MEDICINE