Recent Publications

"ASelective Activity-Dependent Requirement for Dynamin 1 in
Synaptic Vesicle Endocytosis", Science 316: 570

Abstract or Full Text

"Functional Axonal Regeneration Through Astrocytic Scar Genetically Modified to Digest Chondroitin Sulfate Proteoglycans." J Neurosci. 27:2176-2185 (2007).

Abstract or Full Text

"Characterization of myelin ligand complexes with the neuronal Nogo-66 receptor family." J Biol Chem. 282:5715-5725 (2007).

Abstract or Full Text

"The Amino Terminal Domain of Nogo-A Inhibits Cell Adhesion and Axonal Outgrowth by an Integrin-Specific Mechanism."  J Neurosci (2008), in press.

"Release Of MICAL Auto-inhibition By Semaphorin-Plexin Signaling Promotes Interaction With CRMP."  J Neurosci (2008), in press.

"Phosphoinositides' link to neurodegeneration", 2007. Nat. Med. 13: 784-786.

Abstract or Full Text

"Two families of TARP isoforms that have distinct effects on the kinetic properties of AMPA receptors and synaptic currents" , 2007. Neuron, 55, 890-894

Full Text

"A CaM Kinase I/MARK-2 signaling cascade mediates calcium-dependent neurite outgrowth", J. Neurosci, 27 (16) 4413-23

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"Role of calcineurin in nicotine-mediated locomotor sensitization", J. Neurosci, 27 (32): 8571-80

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"AMPA receptors and stargazin-like TARPs mediate hippocampal kainate neurotoxicity. PNAS, 104, 18784-18788.

Peacock, J.G., Miller, A.L., Bradley, W.D., Rodriguez, O, Webb, D.J. and Koleske, A. J. (2007)"The Abl-related gene (Arg) tyrosine kinase acts through p190RhoGAP to inhibit actomyosin contractility and regulate focal adhesion dynamics upon adhesion to fibronectin."Mol Biol. Cell, in press

Sfakianos, M.K."Inhibition of Rho via Arg and p190RhoGAP is required for hippocampal dendritic spine maturation, dendrite stability, and hippocampus-dependent behavior." J. Neurosci., in press.

"SynCAMs organize synapses through heterophilic adhesion". J. Neuroscience 27:12516-12530.

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"Cell-cell interactions in synaptogenesis". Current Opinion in Neurobiology 16:83-89. Review.

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News and Awards

Neuroscientists target disorders of the brain and spinal cord

Neurodegenerative diseases, such as Alzheimer’s, Huntington’s and Parkinson’s, and injuries to the brain and spinal cord from trauma or stroke are among the most feared of the disorders that afflict humankind.....
Medicine@Yale, January/February 2006Vol. 2 Issue 1

Breakthrough in intramembrane proteolysis
Alzheimer's Research Forum

A passionate venture
Alum’s $2.5 million gift to Yale Scholars program spurs study of Alzheimer’s

Henry F. McCance, M.B.A., has a special knack for spotting talent and helping young people to realize their aspirations. Over the course of a 40-year career at Greylock Partners, a venture capital firm in Waltham, Mass., McCance and his partners have.........

Medicine@Yale, March/April 2007 Vol. 3 Issue 2

A scientific assault on brain diseases
Program to unravel Alzheimer’s, Parkinson’s gears up for a tough battle

The School of Medicine is home to outstanding research programs in cell biology and neurobiology, and members of its faculty have made major contributions to our understanding of how nerve cells are organized and function in the brain. However, despite strong clinical programs in Alzheimer’s disease and other........

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