Hebert Laboratory
K+
channelsion-sensorsCl
- transporters TechniquesG-protein coupled ion-sensors
Calcium
and certain other nutrients (amino acids and polyamines) can function as extracellular
signaling molecules or ìfirst messengersî by activating a novel
G protein-coupled receptor that we cloned in 1993. This receptor provides the
mechanism for sensing extracellular calcium and transferring this information
for regulation of the function of many different types of cells. We are studying
the roles of this sensor in epithelial ion and fluid transport, proliferation
and differentiation. This receptor plays important roles in maintaining intestinal
'health'
and
reducing the risk of colon cancer. Representative publications:
Brown, E.M., Gamba, G., Riccardi, D., Lombardi, M., Butters, R., Kifor, O., Sun, A., Hediger, M.A., Lytton, J., and Hebert, S.C.: Cloning and characterization of an extracellular Ca2+-sensing receptor from bovine parathyroid. Nature, 1993; 366:575-580
Nearing, J., Betka, M., Quinn, S., Hentschel, H., Elger, M., Baum, M., Bai, M., Chattopadyhay, N., Brown, E., Hebert, S.C., Harris, H.W.: Polyvalent cation receptor proteins (CaRs) are salinity sensors in fish. PNAS. 2002; 99:9231-9236.
H. Hentschel, J. Nearing, H. W. Harris, M. Betka, M. Baum, S. C. Hebert, and M. Elger. Localization of Mg2+-sensing shark kidney calcium receptor SKCaR in kidney of dogfish, Squalus acanthias. Am.J.Physiol Renal Physiol, 2003; 285:F430-439.
Cheng, S.X.J., Okuda, M., Hall, A.E., Geibel, J.P. and Hebert, S.C.: Expression of calcium-sensing receptor in rat colonic epithelium: Evidence for modulation of fluid secretion. Am. J. Physiol ñ Gastrointestinal Physiol. 2002; 283:G240-G250.
Sam Cheng, Alexandra Buschmann
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