Recent Publications

Okuda, M., Cheng, S.X.J., Hall, A. and Hebert, S.C.: Calcium-Sensing Receptor (CaSR) Inhibits the Activity of Na+, K+-ATPase in the Renal Proximal Tubular Cells. A Mechanism for Urinary Calcium-Mediated Stimulation of Distal Calcium Delivery. 2002; J. Am. Soc. Nephrology. In Preparation.

Meade, P., Hoover, R., Plata, C., V·zquez, N., Bobadilla, N.A., Gamba, G.and Hebert, S.C.: Regulation of the renal-specific mouse Na-K-2Cl cotransporter surface expression by the C-terminal spliced isoform. Am. J. Physiol. - Renal Physiol., 2003; In Press.

Gallazzini, M., Attmane-Elakeb, A., Mount, D.B., Hebert, S.C. and Bichara, M.: Regulation by glucocorticoids and osmolality of expression of ROMK (Kir 1.1), the apical K channel of thick ascending limb. Am. J. Physiol. - Renal Physiol., 2003; In Press.

Wilson, F.H., Kahle, K.T., Sabath, E., Lalioti, M., Rapson, A.K., Hoover, R.S., Hebert, S.C., Gamba, G., and Lifton, R.P.: Molecular pathogenesis of inherited hypertension with hyperkalemia: the Na-Cl cotransporter is inhibited by wild-type but not mutant WNK4. Proc. Natl. Acad. Sci., U.S.A., 2003; 100:680-684.

Hoover, R.S., Poch, E., Monroy, A., Vazquez, N., Nishio, T., Gamba, G., and Hebert, S.C.: N-Glycosylation at two sites critically alters thiazide binding and activity of the rat thiazide-sensitive Na+:Cl- cotransporter. J. Am. Soc. Nephrology. 2003;14(2): 271-282.

Riccardi, D. and Hebert, S.C.: Extracellular CA2+-sensing receptor and kidney function. In: Calcium-Sensing Receptor. Chattopadhyay, N. and Brown, E.M., Eds. 2003; 69-102.

Dong, K., Tang, L.-Q., MacGregor, G.G., Vanoye, C.G. and Hebert, S.C.: Localization of the ATP-binding site to a 39 amino acid region of the COOH-terminus of the ATP-sensitive K+ channel, Kir1.1. J. Biol. Chem. 2002; 277:49366-49373.

Lu, M., Hebert, S.C. and Giebisch, G.: Hydrolyzable ATP and PIP2 modulate small-conductance K+ channel in the apical membrane of rat cortical collecting duct (CCD). J. Gen Physiol. 2002; 120:603-615.

Lu, M., Wang, T., Yan, Q., Yang, X., Dong, K., Knepper, M.A., Wang, W., Giebisch, G., Shull G.E., and Hebert, S.C.: Absence of small-conductance K+ channel (SK) activity in apical membranes of thick ascending limb and cortical collecting duct in ROMK (Bartterís) knockout mice. J. Biol. Chem. 2002; 277:37881-37887.

Vanoye, C.G., MacGregor, G.G., Dong, K., Tang, L.-Q., Hall, A.E., Lu, M., Giebisch, G. and Hebert, S.C.: The carboxy-termini of KATP channels bind nucleotides. J. Biol. Chem. 2002; 277:23260-23270.

Biner, H.L., Arpin-Bott, M.-P., Loffing, J., Knepper, M., Hebert, S.C. and Kaissling, B.: The human cortical distal nephron. Distribution of electrolyte and water transport pathways. J. American Society of Nephrology 2002; 13:836-847.

Plata, C., Meade, P., V·zquez, N., Hebert, S.C. and Gamba, G.: Functional properties of the apical Na-K-2Cl cotransporter isoforms. 2002; J. Biol. Chem. 277:11004-11012.

Nearing, J., Betka, M., Quinn, S., Hentschel, H., Elger, M., Baum, M., Bai, M., Chattopadyhay, N., Brown, E., Hebert, S.C., Harris, H.W.: Polyvalent cation receptor proteins (CaRs) are salinity sensors in fish. PNAS. 2002; 99:9231-9236.

Cheng, S.X.J., Okuda, M., Hall, A.E., Geibel, J.P. and Hebert, S.C.: Expression of calcium-sensing receptor in rat colonic epithelium: Evidence for modulation of fluid secretion. Am. J. Physiol - Gastrointestinal Physiol. 2002; 283:G240-G250.

MacGregor, G.G., Dong, K., Vanoye, C.G., Tang, L.-Q., Giebisch, G. and Hebert, S.C.: Nucleotides and phospholipids compete for binding to the C-terminus of KATP channels. Proc. Natl. Acad. Sci., U.S.A., 2002; 99: 2726-2731.

Loffing, J., Loffing-Cueni, D., Valderrabano, V., Klausli, L., Hebert, S. C., Rossier, B. C., Hoenderop, J. G., Bindels, R. J., and Kaissling, B.: Distribution of transcellular calcium and sodium transport pathways along mouse distal nephron. Am. J. Physiol - Renal Physiol 2002, 281 (6):F1021-F1027.

Sterling, H., Lin, D.-H., Gu, R.-M., Dong, K., Hebert, S.C., and Wang, W. H.: Inhibition of protein tyrosine phosphatase stimulates the dynamin-dependent endocytosis of ROMK1  J. Biol. Chem. 2001, 277(6): 4317-4323.

Dong, K., Xu, J., Vanoye, C.G., Welch, R., MacGregor, G.G., Giebisch, G. and Hebert, S.C.: An Amino Acid Triplet in the NH2-terminus of Rat ROMK1 Determines Interaction with SUR2B. J.Biol.Chem. 2001; 276: 44347-44353.

Riochet, DF., Mohammad-Panah, R., Hebert, SC., MacGregor, GG., Baro, I., Guihard, G., Escande, D.: Inactivating properties of recombinant ROMK2 channels expressed in mammalian cells. Biochem. & Biophys. Res. Comm. 2001; 286(2):376-80.

Greger, R., Schlatter, E. (With Comments by E. Schlatter and S.C. Hebert). Milestones in Nephrology: Presence of luminal K+, a prerequisite for active NaCl transport in the cortical thick ascending limb of Henle's loop of rabbit kidney. J. Am. Soc. Nephrol., 2001; 12:1788-1793.

Moral, Z., Dong, K., Wei, Y., Sterling, H., Deng, H., Ali, S., Gu, R.M., Huang, X-Y., Hebert, S.C., Giebisch, G., and Wang, W.H.. Regulation of ROMK1 channels by protein-tyrosine kinase and tyrosine phosphatase. J. Biol. Chem., 2001; 276:7156-7163.

Plata, C., Meade, P., Hall, A., Welch, R.C., V·zquez, N., Hebert, S.C., and Gamba, G.: Alternatively spliced isoform of the apical Na-K-Cl cotransporter gene encodes a furosemide-sensitive Na+-Cl- cotransporter. Am. J. Physiol.: Renal., 2001; 280:F574-F582.