Hebert Lab: People

Hebert Laboratory

Department of Cellular and Molecular Physiology

Yale School of Medicine

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People

Current lab members:

Steve Hebert
Sam Cheng
Ke Dong
Gordon MacGregor

Qiang Leng
Ming Lu
Anthony O'Connell
Lie-qi Tang

Recent lab members:

Alexandra Buschmann
Matt Bailey

Steve Hebert steve.hebert@yale.edu Steven C. Hebert received his M.D. degree from the University of Florida and his internship and residency training at the University of Alabama. He was on faculty at Harvard University from 1984 to 1996 where he rose to the rank of Professor. After a three year stay at Vanderbilt University as the Ann and Roscoe R. Robinson Professor of Medicine, he joined the faculty at Yale as Professor and Chair of Cellular and Molecular Physiology. " Understanding how cells receive and respond to ionic and metabolic signals is one of the fundamental questions in biology. The path to unraveling these mysteries is an exciting journey."
Sam Cheng sam.cheng@yale.edu Sam enjoys riding his pony around the New Haven green. He also enjoys golf and sky-diving.
Ke Dong ke.dong@yale.edu Ke likes the color pink, breeds lizards, and enjoys driving fast. cars.
Gordon MacGregor gordon.macgregor@yale.edu Gordon MacGregor is from Scotland. He recieved an Honours degree in Biochemistry from the University of St. Andrews, Scotland, in 1991. His Interest in Ion channels led him to further study and a MSc. and PhD. from the University of Dundee, Scotland, in 1995. Gordon is interested in membrane transporters, specifically the family of potassium channels known as inward-rectifiers (Kir). He is currently working on the interplay between pH sensing and phosphorylation in Kir1.1, the secretory potassium channel in the kidney. He is defining the nucleotide binding site on Kir6.2, the metabolic-sensing KATP channel, and studying the interaction of lipids with ATP binding (MacGregor et al., 2002). His most recent interests are the isolation, purification and crystallization of Kir channels. His other interests include, substates of potassium channels, bacterial potassium channels and the evolution of potassium ion channels. When he is not in the lab, Gordon can be found exploring Maine and New Hampshire on his Harley-Davidson.
Qiang Leng Qiang Leng is a native of Shandong, China. He studied physics at Shandong Normal University and was a graduate student at Shandong Agricultural University, where he went on to be a member of the faculty for 13 years. Qiang Leng received his PhD in plant physiology from China Agricultural University in 1998. He is presently a post-doctorate associate in the laboratory of Steven C. Hebert at Yale School of Medicine. Qiang Leng is interested in multidisciplinary research in electrophysiology, molecular biology, pharmacology, structure biology and biophysics. He is currently focusing on understanding structure and function of ion channels in the Kir family using patch-clamp techniques at whole-cell, macroscopic, and single channel levels. qiang.leng@yale.edu
Ming Lu (cftr and romK kidney tubles) ming.lu@yale.edu Ming enjoys roller-skating to work every day and listening to classical music on his computer, pretending the sound waves are ion-channel recordings.
Anthony O'Connell anthony.oconnell@cmp.yale.edu Born in a remote barn on a cattle farm in the north of England, I was nurtured in the ways of rural life until I left home for the Big Smoke, Leeds, some 19 years later. It was Leeds that taught me A) cities don’t have many cows in them, and B) how to drink ‘responsibly’ in front of my peers. While in Leeds, and after a couple of course changes, I completed my first degree in Physiology in 1998. I decided to stay in Leeds and do my Ph.D. with Malcolm Hunter, where I studied the properties of the then newly discovered twin-pore domain potassium channel TASK-1 and TASK-2. After seven years in Leeds, I felt I needed a change. And in 2002, instead of getting a postdoc in Manchester 60 miles down the road, I ended up 3000 miles down the road in New Haven, Connecticut. Here in the Hebert lab (although I use the Gerhard Giebisch lab for my work) I was tasked with a number of projects, some of which worked, some didn’t. But at the moment I’m looking into some properties of the potassium channel ROMK. Much is known about this inward rectifier, particularly its role in potassium handling in the kidney, and my role is to try to find out how ROMK is sent to- and retrieved from the cell membrane by using mutant channels and electrophysiology. When I’m not in the lab I like to uphold the English tradition of beer tasting. I also like to play the drums, and seeing as my kit is at home in England, I sometimes frequent local musical instrument shops to try and get a go on their most expensive drums. On the rare occasions that I’m unchained from the lab bench, I like to get out into the country and get some fresh air. I’m coming back to England at the end of 2003 where I hope to get a postdoc in, you guessed it, the north of England. If that doesn’t work out though, I’m told I’d make an excellent taxi driver…
Lie-Qi Tang lieqi.tang@cmp.yale.edu Lie-Qi received her MD and MSc. from Tong Ji Medical University in China. Her further study in Perinatal Physiology and Developmental Neurobiology was carried on in Karolinska Institute in Stockholm, Sweden. Lie-Qi received a Master of Philosophy in 1999. She is now a post-doctorate associate in Dr. Hebert's Lab at Yale School of Medicine. Lie-Qi is currently working on ATP-sensitive and ATP-regulated potassium channels, mainly focusing on the recombinant protein production and purification, and functional study. Lie-Qi is a mother of 2 wonderful kids in a happy family. She is honest and enthusiasm and enjoys having many friends from all over the world.
Recent Lab Members
Alexandra Buschmann Alexandra has been working on ATP binding to K Channels and the purification of the Calcium sensor and receptor. She returned in August 03 to Berlin to finish her medical degree.
Matt Bailey matthew.bailey@yale.edu Matt is working on purinerigic receptors in renal tubules using classic microelectric techniques. Matt is a Wellcome Traveling Research Fellow and is spending a year in Edinburgh to continue his work before returning to UCL in London.

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Last modified: October 21, 2003

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