Hebert Lab

Hebert Laboratory

Welcome to the Hebert Lab

We are interested in the structural, biochemical and genetic mechanisms involved in the regulation of ion transport and signaling by epithelial cells. The movement of ions through channels is governed by conformational changes resulting in channel opening or closing, also referred to as gating. Ion channels have evolved an array of gating sensors. We utilize molecular-genetic, biochemical and pharmacological approaches to study how nucleotides and protons gate inwardly rectifying K channels. These K channels play vital roles in kidney, heart, vascular smooth muscle, and pancreatic beta-cells. In addition, certain ions like calcium can function as extracellular signaling molecules or "first messengers" by activating a novel G protein-coupled receptor that we cloned in 1993. This receptor provides the mechanism for extracellular calcium-mediated regulation of the function of many types of cells. We are studying the roles of this receptor in epithelial ion and fluid transport, proliferation and differentiation. This receptor plays important roles in maintaining intestinal "health" and reducing the risk of colon cancer.

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Last modified: August 22, 2003